Allergan, Inc.

Gerald W De Vries

Patrick Michael Hughes

Thomas C Malone

Thierry Nivaggioli

Joan-En Chang-Lin

Jane-Guo Shiah

Jane Guo Shiah

Lon T Spada

Scott M Whitcup

Robert T Lyons

Jeffrey L Edelman

Wendy M Blanda

John T Trogden

Jeffery L Edelman

Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into the vitreous of an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants can be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as posterior ocular conditions.

Biodegradable intravitreal tyrosine kinase implants

Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions.

Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods

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Laguna Hills, CA, United States of America

Gerald W De Vries