The State University of New York

New York University

Inspirx, Inc.

Gerald Smaldone

Vijay Shukla

Rany Condos

Akanksha Hande

Rohinton Toddywala

A ventilator circuit apparatus is provided for the administration of an aerosolized drug from a nebulizer through an endotracheal tube to a patient on a mechanical ventilator with humidification of the breathing gases. Means to disconnect the nebulizer without interrupting the airflow to the patient is provided, with a T-fitting and three-way valve in the ventilator circuit that permits the nebulizer to be bypassed by the airflow, allowing the nebulizer to be removed from the apparatus without interrupting the flow of breathing gases to the patient. In embodiment, the nebulizer is breath-enhanced jet nebulizer. In an embodiment, the jet nebulizer is breath-actuated, by the use of an air pressure sensor that toggles the flow of pressurized air to the nebulizer that drives the jet required for nebulization.

Breath actuated nebulizer for ventilator circuit

A breath-enhanced nebulizer adapted for use in administering an aerosolized pharmaceutical composition to a patient by inhalation wherein the patient is connected to a mechanical ventilator is disclosed. The nebulizer has a Venturi driven by a nebulizer air supply that draws a solution of a pharmaceutical composition into a shear zone where the solution is atomized. The Venturi effect is amplified by the internal configuration of the nebulizer to increase the rate of nebulization of drug. Optionally, breath-actuated nebulization is used, employing a pressure sensor interposed between the nebulizer and mechanical ventilator that controls the nebulizer air supply, such that nebulizer air and concomitant nebulization only occurs during the inhalation phase of a breathing cycle.

Breath-enhanced nebulizer for delivery of aerosolized drugs to ventilated patients

Growing community of inventors

Stony Brook, NY, United States of America

Gerald Smaldone