Corning Glass Works

Medical and Scientific Designs Inc.

Gerald R Mansfield

George Halsey Beall

Robert C Beaty

Jan W Schreurs

Nicholas Francis Borrelli

Kevin J Sullivan

Joseph N Panzarino

Albert A Luderer

William P Vann

Karen L Travis

Arthur H Rogers

This invention is directed to a method for reducing the mass of a tumor in animal tissue utilizing localized, magnetically-coupled, RF-induced hyperthermia. The method involves the implanting of a material in and/or closely adjacent to the tumor which is non-toxic to, and preferably inert to and compatible with, normal tissue and which has encapsulated therewithin ferromagnetic particles of such size, amount, composition, and ferromagnetism to develop a heating value of up to about one watt/gram, through essentially only hysteresis heating, under an applied field of about 20 but less than 200 oersteds at a frequency greater than 10 kilohertz and ranging up to about 600 kilohertz, or under an applied field of at least about 2000 oersteds and a frequency below about 40 hertz. Such heating value is sufficient to kill the tumor cells but muscle and nerve response of the animal body to the induced emf is minimized.

Radio frequency-induced hyperthermia for tumor therapy

An inner and outer cylindrical cathode are concentrically positioned about a vertical center axis. Vertical anode electrodes extend parallel to the center axis and are symmetrically arranged around the inter-cylinder space between the cathodes. The ends of the anode wires are supported by a pair of insulator rings mounted near the top and bottom of the cathode cylinders. A collection voltage applied to each anode wire for establishing an inward radial E field to the inner cathode cylinder and an outward radial E field to the outer cathode cylinder. The anode-cathode assembly is mounted within a housing containing a conversion gas. A radioactive sample is inserted into the inner cathode which functions as a tubular, deep well radiation window between the sample environment and the conversion gas environment. A portion of the gamma radiations passing through the inter-cylinder region interact with the conversion gas to produce free electrons which are accelerated by the E fields and collected on the anode wires. The extremely small diameter of the anode wires intensifies the electric fields proximate each wire causing avalanche multiplication of the free electrons resulting in a detectable charge pulse.

Multi-anode deep well radiation detector

The present invention provides a method for making porous bodies of magnetic glass and/or crystal-containing materials having magnetic crystals incorporated therein with dimensions less than about 1000A. Preferably, the crystals have dimensions less than 500A such that the porous bodies demonstrate essential superparamagnetic behavior. The method involves preparing a body which, upon heat treatment, will separate into at least two vitreous phases and at least one crystal phase. One of the vitreous phases is etched away leaving a structure remaining which contains said magnetic crystals. When present as fine particles, the porous magnetic bodies are especially suitable for use in biological assays.

Method for making porous magnetic glass and crystal-containing structures

Solid-phase immunoassay procedures employing magnetic glass or crystal-containing material, or a superparamagnetic material formed of magnetic particles dispersed in a non-magnetic matrix, as particulate carrier.

Solid-phase immunoassays using magnetic glass

A control system for a slide centrifuge includes a ratio checking circuit which produces a signal when the ratio between the light passing through the slide and the rate of change of this light passes through a predetermined critical value. When this ratio passes through the critical valve, spinning is stopped. This effectively stops spinning when the rate of reduction of blood cell density on the slide slows, thereby producing better slides for clinical analysis.

Control system for a slide centrifuge

Porous magnetic glass structure

A control system for a slide centrifuge includes a ratio checking circuit which produces a signal when the ratio between the light passing through the slide and the rate of change of this light passes through a predetermined critical value. When this ratio passes through the critical value, spinning is stopped. This effectively stops spinning when the rate of reduction of blood cell density on the slide slows, thereby producing better slides for clinical analysis.

Growing community of inventors

Painted Post, NY, United States of America

Gerald R Mansfield