Laboratoire Francais Du Fractionnement Et Des Biotechnologies

Gerald Perret

Nicolas Bihoreau

Sami Chtourou

Michel Nogre

Laurent Siret

Agnes Cibiel

An affinity substrate for the selective binding of a protein of blood plasma includes a solid substrate material on which are immobilized deoxyribonucleic aptamers specifically binding with the plasma protein.

Affinity substrate and methods for selectively purifying a blood plasma protein

A method for purifying GLA-domain coagulation proteins, includes the following steps: a) bringing a sample containing one or more GLA-domain coagulation proteins into contact with an affinity substrate on which nucleic aptamers which bind specifically to the GLA-domain coagulation proteins are immobilized, in order to form complexes between (i) the nucleic aptamers and (ii) the GLA-domain coagulation protein(s), b) releasing the GLA-domain coagulation protein(s) from the complexes formed in step a), and c) recovering the GLA-domain coagulation protein(s) in a purified form.

Method for purifying GLA-domain coagulation proteins

The invention relates to nucleic acid aptamers binding specifically to factor H, to a method for obtaining same, and to the uses thereof, in particular for the purposes of purifying factor H.

Anti-FH aptamers, method for producing same, and uses thereof

A method for measuring immunoglobulin G-mediated complement activation, includes the following steps:

Growing community of inventors

Choisy le Roi, France

Gerald Perret