Northwest Biotherapeutics, Inc.

Medarex Inc.

Other

Pacific Northwest Cancer Foundation

Northwest Hospital

Gerald P. Murphy Cancer Foundation

Gerald P Murphy

Alton L Boynton

Eric H Holmes

William T Tino

Anil Sehgal

Robert J Barren, Iii

Benjamin A Tjoa

The present invention relates to the identification of a novel role of CXCR-4 in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered gene expression of CXCR-4 in a number of primary tumors and cell lines derived from tumors, in addition to, the altered gene expression of ligands for CXCR-4. Further, the present invention relates, in part, to the Applicants' surprising discovery that the inhibition of CXCR-4 gene expression or the inhibition of CXCR-4 activity in transformed cells reverses the transformed phenotype.

Therapeutic and diagnostic applications based on the role of the CXCR-4 gene in tumorigenesis

An apparel accessory holder is described. An elongated panelis suspended by a hookincludes a rod engaging mechanism such as a fixed or swiveling hook for suspending the panelfrom astandardsupport rodalready in place, such as an in-closet rod. Onesideor both sidesof the panelcontainsincludesa series ofhook and loop locking padsaccessory holdersfor securing heavy and bulky items such as handbags,while the opposite side contains a series of gentle magnetic locking pads for delicate,and/oramorphous items such as scarves. Thehook connection permits swiveling the panel left and right or up and down 360&#xb0;rod engaging mechanism facilitates easy placement of the accessory holder on the closet rod with removal and replacement facilitated. Written indicia guide the user to recommended storage procedures; and making one side softer to the touch provides an additional sensory direction to the user. The holder provides added convenience for apparel accessory storage and retrieval within the home, and for a variety of merchandise displays.

Apparel accessory holder

The present invention relates to the identification of a novel role of CXCR-4 in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered gene expression of CXCR-4 in a number of primary tumors and cell lines derived from tumors, in addition to, the altered gene expression of ligands for CXCR-4. Further, the present invention relates, in part, to the Applicant's surprising discovery that the inhibition of CXCR-4 gene expression or the inhibition of CXCR-4 activity in transformed cells reverses the transformed phenotype.

A card holder and dispensing device comprises a rectangularly shaped frame member including upper, lower and side perimeter segments. These form an enclosure into which is placed a plurality of, typically, plastic cards. The upper and lower segments form an open area which is less than the surface area of the cards so that they can't be removed through these openings. A card retention tab extends from one of the side perimeter segments beyond the enclosure formed by the frame member. This restrains movement of the cards out of the card insertion opening. One of the top frame segments includes a tab section which is typically biased downward into the enclosure volume to exert a downward force on the stored cards. This permits the user to move one or more of the cards partially out of the enclosure until the desired card is reached and assists in the removal of the desired card. The tab section can be variously shaped, sized and contoured to accommodate printed indicia.

Card holder and dispensing device

An apparel accessory holder is described. An elongated panel is suspended by a hook from a standard support rod. One side of the panel contains a series of hook and loop locking pads for securing heavy and bulky items such as handbags, while the opposite side contains a series of gentle magnetic locking pads for delicate, amorphous items such as scarves. The hook connection permits swiveling the panel left and right or up and down 360&#xb0;. Written indicia guide the user to recommended storage procedures; and making one side softer to the touch provides an additional sensory direction to the user. The holder provides added convenience for apparel accessory storage and retrieval within the home, and for a variety of merchandise displays.

The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate-specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods of using such antibodies for diagnosis and treatment of cancer. In particular, thirty-five monoclonal antibodies reactive with PSMA expressed on the cell surface are exemplified. Additionally, the present invention relates to a novel protein variant (PSM') of PSMA detected by a number of the antibodies of the invention. The hydrolase activity of PSMA and PSM&#x2032; allows the use of an immunoenzymatic assay for their detection.

Monoclonal antibody specific for the extracellular domain of prostate specific membrane antigen

Monoclonal antibodies specific for the extracellular domain of prostate-specific membrane antigen

Accessory holder

The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate-specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods of using such antibodies for diagnosis and treatment of cancer. In. particular, thirty-five monoclonal antibodies reactive with PSMA expressed on the cell surface are exemplified. Additionally, the present invention relates to a novel protein variant (PSM') of PSMA detected by a number of the antibodies of the invention. The hydrolase activity of PSMA and PSM&#x2032; allows the use of an immunoenzymatic assay for their detection.

The present invention relates to the identification of a novel role of Nr-CAM in cell transformation and aberrant cellular proliferation. In particular, the present invention relates to the altered gene expression of Nr-CAM in a number of primary tumors and cell lines derived from tumors, in addition to, the altered gene expression of ligands for Nr-CAM. Further, the present invention relates, in part, to the Applicants' surprising discovery that the inhibition of Nr-CAM gene expression or the inhibition of Nr-CAM activity in transformed cells reverses the transformed phenotype.

[object Object]

The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate-specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods of using such antibodies for diagnosis and treatment of cancer. In particular, thirty-five monoclonal antibodies reactive with PSMA expressed on the cell surface are exemplified. Additionally, the present invention relates to a novel protein variant (PSM') of the PSMA detected by a number of the antibodies of the invention. The hydrolase activity of PSMA and PSM&#x2032; allows the use of an immunoenzymatic assay for their detection.

The present invention is directed to methods of detecting prostate cancer in a sample of a body fluid with prostate cell marker-specific and epithelial cell marker-specific antibodies as well as to kits comprising such antibodies for use in the detection of prostate cancer. The present invention is also directed to methods of detecting prostate cancer in a sample of a body fluid with prostate cell marker-specific and tumor associated marker-specific antibodies as well as to kits comprising such antibodies for use in the detection of prostate cancer.

Non-invasive method to detect prostate cancer

Non-invasive methods to detect prostate cancer

The present invention relates to monoclonal antibodies that bind to the extracellular domain of prostate-specific membrane antigen (PSMA), hybridoma cell lines producing the antibodies, and methods of using such antibodies for diagnosis and treatment of cancer. In particular, thirty-five monoclonal antibodies reactive with PSMA expressed on the cell surface are exemplified. Additionally, the present invention relates to a novel protein variant (PSM') of PSMA detected by a number of the antibodies of the invention. The hydrolase activity of PSMA and PSM' allows the use of an immunoenzymatic assay for their detection.

Growing community of inventors

Seattle, WA, United States of America

Gerald P Murphy