Psma Development Company, LLC

Amgen Fremont Inc.

Progenics Pharmaceuticals, Inc.

Gerald P Donovan

William C Olson

Dangshe Ma

Paul J Maddon

Norbert Schuelke

Jason Gardner

Larry L Green

Jaspal Singh Kang

Naoya Tsurushita

Shankar Kumar

Albert Cupo

Kirsten Nagashima

Brian Kennedy

Yun Kang

Andre J Marozsan

Norbert Schulke

The invention includes stable multimeric, particularly dimeric, forms of PSMA protein, compositions and kits containing dimeric PSMA protein as well as methods of producing, purifying and using these compositions. Such methods include methods for eliciting or enhancing an immune response to cells expressing PSMA, including methods of producing antibodies to dimeric PSMA, as well as methods of treating cancer, such as prostate cancer.

PSMA antibodies and uses thereof

Provided herein are reagents, compositions, and therapies with which to treatinfection and related disease conditions and pathologies, such as-associated diarrhea, resulting from infection bybacteria and the enterotoxins produced by these bacteria. In particular, antibodies or antigen-binding fragments thereof that bind specifically to toxin A and/or toxin B ofand neutralize the activities of these toxins; compositions comprising such antibodies; and methods of using the antibodies and the compositions are provided.

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The invention includes antibodies or antigen-binding fragments thereof which bind specifically to conformational epitopes on the extracellular domain of PSMA, compositions containing one or a combination of such antibodies or antigen-binding fragments thereof, hybridoma cell lines that produce the antibodies, and methods of using the antibodies or antigen-binding fragments thereof for cancer diagnosis and treatment. The invention also includes oligomeric forms of PSMA proteins, compositions comprising the multimers, and antibodies that selectively bind to the multimers.

Compositions of PSMA antibodies

PSMA antibodies and protein multimers

Growing community of inventors

Kittery, ME, United States of America

Gerald P Donovan