Other

The General Hospital Corporation

Alliance Pharmaceutical Corp.

Gerald L Wolf

Vladimir S Trubetskoy

Vladimir P Torchilin

G Scott Gazelle

David M Long, Jr

Mikhail Chernov

The invention features a method for selectively ablating tumor-forming, glandular tissue in a breast by exposing the breast to microwave radiation that ablates glandular tissue while avoiding damage to the fatty tissues of the breast.

Selective ablation of glandular tissue

Laryngoscope blade

An amphipathic polychelating compound including a hydrophilic polymeric moiety having a main backbone and a plurality of reactive side groups, a lipid-soluble anchor linked to the N terminal of the polymeric moiety, and a plurality of chelating agents linked to the side groups of the polymeric moiety. The polychelating compounds are bound to liposomes or micelles for use as diagnostic and therapeutic agents.

Amphipathic polychelating compounds and method of use

A radiographic imaging agent including a plurality of block copolymers forming a micelle, the block copolymers including a hydrophilic polymer linked to a hydrophobic polymer, and the hydrophobic polymer including a backbone incorporating radiopaque molecules via covalent bonds.

Targeted co-polymers for radiographic imaging

Composotions and methods for radiographic imaging

Amphipathic polychelating compounds and methods of use

Injectable contrast agents of great clinical importance for lymphography, characterized by non-water soluble particle sizes between about 5 or 10 nm and about 500 or 900 nm, which have selective distribution to lymph nodes upon percutaneous administration and can be imaged with millimeter resolution. Also disclosed are methods for performing percutaneous lymphography using these contrast agents.

Percutaneous lymphography

Percutaneous lymphography using particulate fluorocarbon emulsions

A method of reversibly occluding a biological tube is provided as well as a related apparatus. The method includes providing an occluding member to be introduced into or around a biological tube thereby blocking flow through the tube. When it is desired to eliminate such blockage, shock wave lithotripsy or other energy is employed to fragment the occluding member and thus eliminate its blockage of the biological tube. The related occluding device comprises an occluding member having an inner core of a first rigid material encapsulated in an outer shell comprised of a flexible second material. The first will fragment when struck by shock waves. The device may be either a plug-type device or a C-shaped clamp. Alternatively, the device may be comprised of a single material which is introduced in flowable form into the tube by means of a catheter. The material then hardens to form a substantially rigid plug.

Method and apparatus for reversibly occluding a biological tube

A method of reversibly occluding a biological tube is provided as well as a related apparatus. The method includes providing an occluding member to be introduced into or around a biological tube thereby blocking flow through the tube. When it is desired to eliminate such blockage, shock wave lithotripsy or other energy is employed to fragment the occluding member and thus eliminate its blockage of the biological tube. The related occluding device comprises an occluding member having an inner core of a first rigid material encapsulated in an outer shell comprised of a flexible second material. The first will fragment when struck by shock waves. The device may be either a plug-type device or a C-shaped clamp.

Growing community of inventors

Winchester, MA, United States of America

Gerald L Wolf