Bristol-myers Squibb Compnay

Gerald L Powers

David R Kronenthal

Sushil K Srivastava

Jollie D Godfrey, Jr

John J Venit

Nachimuthu Soundararajan

Paul Alan Jass

John L Dillon, Jr

Keith Ramig

Ambarish K Singh

Saibaba Racha

Mark D Schwinden

Atul S Kotnis

John K Thottathil

Ramesh N Patel

David J Kucera

Richard P Polniaszek

William John Winter

Chenkou Wei

Purushotham Vemishetti

Milan N Stojanovic

Victor W Rosso

Chung-Pin H Chen

Amit Banerjee

Peter Timmins

Yadagiri R Pendri

Jeffrey M Evans

Shaopeng Wang

Zhongping Shi

Maotang X Zhou

Jeffrey T Bien

Jing Liang

Sunil S Patel

Siva Josyula Prasad

Raymond E Weaver

Dhileepkumar Krishnamurty

Yeung Yu Chan

Sushil K Rijhwani

Charles Lewis

Alison E Bretnall

Yeung Y Chan

Milan Stojanovic

Processes are disclosed for preparing the antiviral agent entecavir. A resin adsorption process for the isolation and purification of entecavir is also disclosed. Various intermediates useful in the preparation of entecavir are also disclosed.

Process for preparing the antiviral agent [1S-(1alpha,3 alpha,4beta )]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one

Preparation of (S)-2-amino-6,6-dimethoxyhexanoic acid methyl ester via novel dioxolanes

Preparation of (s)-2-amino-6,6-dimethoxyhexanoic acid methyl ester via novel dioxolanes

Novel reaction conditions for the cleavage of silyl ethers from silyl protected taxane precursors to afford paclitaxel and paclitaxel analogues in high yield and quality are described. Paclitaxel is prepared from a taxane precursor by treating the taxane precursor with a strong acid such as trifluoroacetic acid in a solvent such as aqueous acetic acid, such that the amount and number of side reactions and taxane impurities are significantly minimized. Also desribed are the crystallization methods for the isolation of paclitaxel in either of the two crystal forms A or B. Paclitaxel and paclitaxel analogues are anti-cancer agents.

Reaction conditions for the cleavage of silyl ethers in the preparation of paclitaxel(taxol&reg;) and paclitaxel analogues

Novel salts of the antidiabetic agent metformin acre provided which are metformin salts of dibasic acids (2:1 molar ratio), preferably metformin (2:1) fumarate and metformin (2:1) succinate, which may be employed alone or in combination with another antihyperglycemic agent such as glyburide, for treating diabetes. A method for treating diabetes employing the novel metformin salt by itself or in combination with another antidiabetic agent is also provided.

Salts of metformin and method

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North Brunswick, NJ, United States of America

Gerald L Powers