University of Utah Research Foundation

Other

Gerald Krueger

Nicholas Benson

A liquid is placed on an area of skin in which an RNA sample is to be extracted. The liquid is configured to harden which allows for the hardened material to be peeled off. In some implementations, a substrate is attached to the liquid before it hardens to facilitate removal of the skin sample.

Non-invasive recovery of RNA and analysis of gene expression in skin

Sprinkler

The invention provides a connector for a rotatable lawn sprinkler mounted on a cylindrical stand pipe, and comprises two cylindrical members arranged co-axially with respect to the longitudinal axis of the stand pipe. A cylindrical sleeve, as the female member of the connector, has an open-ended longitudinal bore and terminates at one end with an outwardly extending annular shoulder seated on the marginal wall of the stand pipe and is secured thereto. A cylindrical stem, as the male member of the connector, having an open-ended longitudinal bore and terminates near one end with an outwardly extending annular collar is co-axially disposed and slidably engagable with the sleeve so as to be freely rotatable in the bore of the sleeve. The annular collar of the stem is supportably engaged with the annular shoulder of the sleeve. The upper section of the stem is adaptable for secure engagement with the rotatable lawn sprinkler. A hose is connected near the bottom of the stand pipe, and when water is supplied through the hose to the stand pipe and through the bores of the sleeve and stem, which all are in fluid communication, because the sprinkler is provided with one or more restricted orifices, the resulting water pressure effects common rotation of the stem and the lawn sprinkler.

Connector for lawn sprinkler

Base for sprinkler

Methods and testing models for use in testing the effects of substances on human skin without the need for human subjects. The present invention includes a flap having viable, functional human skin on one side and animal skin on the opposite side. Sandwiched between the layers of skin are one or more isolated veins, arteries, and nerves. This isolated vasculature joins the animal and the skin flap. The human skin layer is simply a split thickness skin graft prepared from living, but discarded, human skin. The present invention allows various substances to be applied directly to the human skin. The presence of absence of the substance can then be detected in the blood flowing in the isolated vasculature. Thus, tests involving living human skin can be performed without the need to directly involve human subjects.

Growing community of inventors

Marquette, WI, United States of America

Gerald Krueger