American Cyanamid Company

Gerald J Siuta

Seymour Bernstein

Ransom B Conrow

John F Poletto

Martin J Weiss

Methods of use and compositions of matter of certain ureides of substituted naphthalenesulfonic acids and salts thereof, useful as inhibitors of connective tissue destruction.

Ureylenebis (hydroxy naphthalenesulfonic acids)

Novel ureylenebis[substituted-phenylenecarbonyl(and sulfonyl)imino-substituted-phenylenesulfonylimino-naphthalenetrisulfonic acid hexaalkali metal salts], useful as inhibitors of the complement system of warm-blooded animals, the amino-substituted phenylenecarbonyl (and sulfonyl)imino-substituted-phenylenesulfonylimino-naphthalenetrisulfonic acid, trialkali metal salts, which are new intermediates for the preparation of the active ureylenes, and the process for their preparation.

Ureylene phenylene anionic naphthalenesulfonic acids

Novel ureylenebis-[substituted-phenylenecarbonylimino-substituted-phenylenesulfo nylimino]naphthalenetrisulfonic acid alkali metal salts], useful as inhibitors of the complement system of warm-blooded animals, the amino-substituted phenylenecarbonyl imino, substituted-phenylenesulfonylimino-naphthalenetrisulfonic acid, alkali metal salts, which are new intermediates for the preparation of the active ureylenes, and the process for their preparation.

Novel ureylenebis[substituted-phenylenecarbonyl(and sulfonyl)imino-subsituted-phenylenesulfonylimino-naphthalenetrisulfonic acid hexaalkali metal salts], useful as inhibitors of the complement system of warm-blooded animals, the amino-substituted phenylenecarbonyl(and sulfonyl)imino-substituted-phenylenesulfonylimino-na phthalenetrisulfonic acid, trialkali metal salts, which are new intermediates for the preparation of the active ureylenes, and the process for their preparation.

This disclosure describes certain 11-(2-hydroxyethylthio) prostenoic acid E and F series derivatives, and their intermediates, useful as bronchodilators and inflammatory medeator release inhibitors.

11-(2-Hydroxyethylthio) prostenoic acid E and F series derivatives

This disclosure describes certain 11-(2-hydroxyethylthio)-9-keto-prostenoic acid E series derivatives, and their intermediates, useful as bronchodilators and inflammatory medeator release inhibitors.

11-(2-Hydroxyethylthio)prostenoic acid E series derivatives

Novel ureylenebis-[substituted-phenylenecarbonylimino-substituted-phenylenecarbo nylimino-naphthalenetrisulfonic acid, alkali metal salts], useful as inhibitors of the complement system of warm-blooded animals, the amino-substituted phenylenecarbonylimino, substituted-phenylenecarbonylimino-naphthalenetrisulfonic acid, alkali metal salts, which are new intermediates for the preparation of the active ureylenes, and the process for their preparation.

A method of inhibiting the complement system in a warm-blooded animal which comprises the administration of a ureylenebis-[substituted-phenylenecarbonyl (and sulfonyl) imino-substituted-phenylene carbonylimino-naphthalenetrisulfonic acid, hexaalkali metal salt].

Ureylene phenylene anionic naphthalenesulfonic acids as complement

Novel ureylenebis[substituted-phenylenecarbonyl-(and sulfonyl)imino-substituted-phenylenesulfonylimino-naphthalenetrisulfonic acid hexaalkali metal salts], useful as inhibitors of the complement system of warm-blooded animals, the amino-substituted phenylenecarbonyl (and sulfonyl)imino-substituted-phenylenesulfonylimino-naphthalenetrisulfonic acid, trialkali metal salts, which are new intermediates for the preparation of the active ureylenes, and the process for their preparation.

11-(2-Hydroxyethylthio) prostenoic acid E series derivatives

5,5'-[5-Nitro-1,3-phenylenebis(carbonylimino)]disalicyclic acid and 5,5'-[5-amino and nitro-1,3-phenylenebis(carbonylimino)]bis[3-sulfosalicylic acid]dialkali metal salts useful as complement inhibitors.

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Yonkers, NY, United States of America

Gerald J Siuta