National Research Development Corporation

Warner-Lambert Company

British Technology Group Limited

British Tech. Group

Gerald E Adams

Ian J Stratford

Edward M Fielden

Howard D Showalter

Israr Ahmed

Matthew A Naylor

Vladimir Genukh Beylin

Anthony Denver Sercel

Terence C Jenkins

David Gibson

Vladimir G Beylin

Anthony D Sercel

Pauline Joy Wood

Chiral compounds useful as radiosensitizers or chemosensitizers having the formula ##STR1## wherein X is halogen or ##STR2## intermediates used to prepare these compounds, and a novel process to prepare these compounds are described.

Chiral [[(2-bromoethyl)-amino]methyl]-2-nitro-1H-imidazol-1-ethanol and

A human or animal subject having a solid tumour is treated by administering to the subject therapeutically effective amounts of a nitric oxide (NO) synthase inhibitor and a compound which is an imidazole or 1,2,4-triazole derivative of formula (A) ##STR1## wherein X is selected from the group consisting of ##STR2## wherein R is hydrogen or a C.sub.1 -C.sub.6 alkyl group; each of R'.sub.1 to R'.sub.5 is independently selected from the group consisting of hydrogen, C.sub.1 -C.sub.6 alkyl, hydroxy(C.sub.1 -C.sub.6 alkyl), phenyl, (C.sub.1 -C.sub.6 alkyl)phenyl and phenyl(C.sub.1 -C.sub.6 alkyl); m is 0 or 1; n is 1 or 2; and Z' represents a leaving group which has the potential for expulsion via an intramolecular cyclisation reaction and which is not negatively-charged; or a physiologically acceptable acid addition salt thereof.

Potentiation of bioreductive agents

Process for preparing chiral

A compound for treating a patient having a solid tumor in which it is known or suspected that hypoxic cells are present, which is a compound of formula (A): ##STR1## wherein X represents a nitro-substituted aromatic or hetero-aromatic group with a one-electron reduction potential at pH 7 of from -250 to -500 mV; each of R'.sub.1 to R'.sub.5 independently represents hydrogen or an alkyl, hydroxyalkyl, aryl, aralkyl or alkaryl group; m is 0 or 1; n is 1 or 2; and Z' represents a leaving group which has the potential for expulsion via an intramolecular cyclization reaction; or a physiologically acceptable acid addition salt thereof.

Nitro-substituted aromatic or hetero-aromatic compounds for use in

A compound of formula I ##STR1## in which formula: R.sub.1 represents hydrogen or an alkyl group;

Intermediate 1-(2-nitro-1-imidazolyl)-3-substituted amino-2-propanols

Useful in radiotherapy of chemotherapy

A chemopotentiating or radiation sensitizing compound of formula I ##STR1## in which formula: R.sub.1 represents hydrogen or an alkyl group;

Imidazole compounds useful in radiotherapy or chemotherapy and

Aziridino containing nitro imidazoles and pharmaceutical compositions

Growing community of inventors

Wheatley, United Kingdom

Gerald E Adams