Alcon, Inc.

Novartis Ag

Hrl Laboratories, LLC

Bolt Medical, Inc.

Melles Griot Limited

Gerald David Bacher

Ronald T Smith

Alireza Mirsepassi

Michael James Papac

Cesario Pereira Dos Santos

David M Pepper

Eric A Schultheis

Mark David LaBelle

Steven Thomas Charles

Zsolt Bor

Bruno F Pouet

Eyad Ammari

Ryan Makoto Takakawa

Christopher A Cook

David E Hargis

Mark Harrison Farley

John F Black

Gilmore Joseph Dunning

Marvin E Klein

Brian William McDonell

Paul R Hallen

Andrew David Johnson

Yu Liu

Bruno X Lassalas

Dan V Teodorescu

Conrad Sawicz

Dean Richardson

Omeed Paydar

Mikhail Ovchinnikov

Derek Y Chen

Mina Mossayebi

Nikki Koe

Wenjie Xie

Systems and methods are disclosed for measuring pulsed laser output. An example system comprises a laser configured to emit output in pulses; at least one sensor positioned to sense laser output and configured to convert that output into electrical signals; an edge detector configured to detect at least leading edges of a plurality of laser pulses; an analog to digital converter configured to convert electrical signals from a sensor into digital signals indicative of laser power output; and a controller; wherein, based on the detection of at least the leading edges of the laser pulses, the controller is configured to obtain samples of laser power output during each of the laser pulses. The system may use the samples of laser power output in a feedback loop to automatically adjust laser power.

Measurement of pulsed laser output using optical detection of duty cycle

A catheter system for treating a vascular lesion within or adjacent to a vessel wall within a body of a patient includes a single light source that generates light energy, a first light guide and a second light guide, and a multiplexer. The first light guide and the second light guide are each configured to selectively receive light energy from the light source. The multiplexer receives the light energy from the light source in the form of a source beam and selectively directs the light energy from the light source in the form of individual guide beams to each of the first light guide and the second light guide.

Multiplexer for laser-driven intravascular lithotripsy device

In certain embodiments, a system for sensing occlusions in an optical system includes a first laser source configured to generate optical signals and a set of optical elements arranged to receive the optical signals from the first laser source and to direct the optical signals along a beam path. The system also includes a detector arranged to receive reflections of the optical signals traveling along at least a portion of the beam path and a control system communicably coupled to the detector. The control system is configured to detect, based on signals generated by the detector, reflection signals associated with the reflections of the optical signals, and disable a second laser source based on detection of the reflection signals.

Occlusion sensing in ophthalmic laser probes

Systems and methods for creating multi-spot laser light beams, multiplexing an illumination light and the multi-spot laser light beams, delivering the multiplexed light to a surgical handpiece via a multi-core optical fiber cable, and delivering the multiplexed light onto patient anatomy.

Multiple-input-coupled illuminated multi-spot laser probe

A catheter system for treating a treatment site within or adjacent to a vessel wall or a heart valve includes an energy source, a balloon, an energy guide, and an electrical analyzer assembly. The energy source generates energy. The balloon is positionable substantially adjacent to the treatment site. The balloon has a balloon wall that defines a balloon interior that receives a balloon fluid. The energy guide is configured to receive energy from the energy source and guide the energy into the balloon interior. The electrical analyzer assembly is configured to monitor a balloon condition during use of the catheter system. The electrical analyzer assembly can include a first electrode, a second electrode, and an impedance detector that is electrically coupled to the first electrode and the second electrode. The impedance detector is configured to detect impedance between the first electrode and the second electrode.

Electrical analyzer assembly for intravascular lithotripsy device

Certain embodiments describe an endoilluminator comprising a probe housing an optical fiber. The probe comprises a distal end with an opening through which a first light from a distal end of the optical fiber is configured to be propagated. The probe comprises one or more side openings through which a second light from one or more sides of the optical fiber is configured to be propagated. The endoilluminator also comprises a handpiece coupled to a light source and the proximal end of the probe, wherein the light source is configured to drive light into the optical fiber.

Wide-angle endoilluminator

Mechanical optics for mode mixing may be used to homogenize different modes in an optical fiber used for surgical illumination. A mechanical optical element, such as a rotating prism or a mirror membrane, may impart motion to an incident beam entering the optical fiber to generate a homogeneous illumination field from a coherent light source.

Mechanical optics for mixed mode surgical laser illumination

Pixelated array optics for mode mixing may be used to homogenize different modes in an optical fiber used for surgical illumination. A pixelated phase array, such as a digital micromirror device or an LCD phase plate, may impart motion to an incident beam entering the optical fiber to generate a homogeneous illumination field from a coherent light source.

Pixelated array optics for mixed mode surgical laser illumination

The present disclosure provides a vitreous visualization system including a general light source, a general conduit that transmits light from the general light source through a conduit portion of a general illumination optical fiber, and a combined vitreous visualization and general illumination tool that receives light from the general conduit. The combined vitreous visualization tool includes a vitreous visualization light source, a controller for the vitreous visualization light source, a vitreous visualization optical fiber, a tool portion of the general illumination optical fiber, and a probe tip through which at least parts of both the vitreous visualization optical fiber and the tool portion of the general illumination optical fiber pass.

Systems and methods using a vitreous visualization tool

In a general aspect, a vitrectomy system is adapted to use photodisruption to rupture eye tissue. In some aspects, a photodisruption-based vitrectomy system includes a laser source configured to generate optical pulses having a pulse energy greater than a threshold energy for causing photodisruption in vitreous humor. The system also includes an optical switching device arranged to receive an output of the laser source, and an optical fiber with multiple cores that is arranged to receive an output of the optical switching device. The optical switching device is configured to select a core of the optical fiber and direct optical pulses received from the laser source into the selected core.

Photodisruption-based vitrectomy system

Focusing optics for mode mixing may be used to homogenize different modes in an optical fiber used for surgical illumination. A vibration stage may impart mechanical motion to a condenser lens to generate a homogeneous illumination field from a coherent light source.

Focusing optics for mixed mode surgical laser illumination

Fiber-based mode mixing techniques may be used to homogenize different modes in an optical fiber used for surgical illumination. A vibrating fiber mechanism may impart mechanical motion to a portion of the optical fiber to generate a homogeneous illumination field from a coherent light source.

Fiber-based mode mixing techniques for surgical laser illumination

The present disclosure provides a system and method for monitoring phototoxicity caused by vitreous visualization device ('VVD') illumination during ophthalmic surgery. The systems and methods determine the cumulative amount of optical energy incident on the retina, which corresponds to phototoxicity, the distance between a cutter of the VVD and the retina, and areas where the vitreous has been removed, or any combination thereof. The disclosure further provides a method for monitoring and preventing phototoxicity caused by VVD illumination during ophthalmic surgery. The method may further include determining the distance between a cutter of the VVD and the retina, and determining areas where the vitreous has been removed based on focus areas of the retina that the plurality of light spots has contacted.

System and method for monitoring phototoxicity during ophthalmic surgery

The present disclosure provides a vitreous visualization system including a vitreous illuminator including a vitreous visualization light source and a vitreous visualization tool that transmits lights from the vitreous visualization light source into an eye having vitreous, a pupil, and a vitreous-pupil axis. The vitreous visualization system further includes a general illuminator, which may include a general light source and a general illumination tool that transmits light from the general light source into the eye. The present disclosure further provided a vitreous visualization system including only a vitreous illuminator that transmits light from the vitreous visualization light source into an eye having vitreous, a pupil, a vitreous-pupil axis, and a retina at an angle B with the vitreous-pupil axis of the eye such that the brightness of vitreous in the eye is higher than the brightness of the retina of the eye.

Vitreous visualization system and method

Frequency-based mode mixing may be used to homogenize different modes in an optical fiber used for surgical illumination. A laser modulator may introduce frequency modulation to laser light to generate a homogeneous illumination field due to increased mode mixing in the optical fiber.

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Carlsbad, CA, United States of America

Gerald David Bacher