The Procter Gamble Company

Norwich Eaton Pharmaceuticals, Inc.

Gerald B Kasting

Thomas L Cupps

Joseph H Gardner

Joel I Shulman

Thomas W Gibson

Ronald L Smith

Richard S Echler

John Michael Gardlik

John M Janusz

Donald Lynn Bissett

Adam W Mazur

Thomas R LaHann

Maurice E Loomans

Timothy P O'Neill

Gary A Piazza

William E Snyder

Eugene G Drust

Joan B Szkutak

Kay Lesley Powers

Ellen R Massaro

The subject invention relates to compositions which are useful for improving the visual appearance of skin, especially facial skin. The composition contains certain primary actives including at least one cyclic polyanionic polyols at least one sulfhydryl compound and at least one zwitterionic surfactant. The subject invention further relates to methods of improving the visual appearance of skin.

Compositions for visually improving skin

The present invention provides methods of preventing lesions due to herpes simplex infections in humans and lower animals by treatment with natural and synthetic vanilloid compounds.

Use of vanilloids for the prevention of lesions due to herpes simplex

The subject invention relates to methods of regulating skin wrinkles and/or atrophy in mammalian skin comprising topically applying to the skin of a mammal in need of treatment a composition comprising a safe and effective amount of a cyclic polyanionic polyol derivative having the structure: ##STR1## wherein n is an integer from 1 to 3; and each X is, independently, selected from the group consisting of OSO.sub.3.sup.-, OPO.sub.3.sup..dbd., SO.sub.3.sup.--, PO.sub.3.sup..dbd., CO.sub.2.sup.--, and OH; with at least 3 X's being other than OH.

Methods of using cyclic polyanionic polyol derivatives for regulating

The subject invention relates to compositions and methods for regulating wrinkles in mammalian skin by topical application of a 2-deoxy- or 2-deoxy-2-halo-lysophosphatidic acid compound having the structure: ##STR1## or a pharmaceutically acceptable salt thereof, wherein --R is unsubstituted or substituted, saturated or unsaturated, straight or branched chain alkyl having from 11 to about 23 carbon atoms; each --X-- is independently --0-- or --S--; --Y-- is --0-- or --CH.sub.2 --; and Z is --H or halo.

Topical composition and method containing deoxy and halo derivatives of

The present invention relates to beta-aminoethyl-substituted phenyl compounds, especially beta-aminoethoxy-substituted phenyl compounds. The present invention also relates to pharmaceutical compositions comprising a safe and effective amount of a compound of the present invention and a pharmaceutically-acceptable carrier. The present invention further relates to methods for producing analgesia and reducing inflammation, in humans and lower animals, by administering the compounds or compositions of the present invention. In addition, the present invention relates to methods for making compounds of the present invention and intermediates useful in these synthesis methods.

Novel compounds, pharmaceutical compositions, and methods for treating

Topical pharmaceutical compositions containing a specific 6-amino-1,2-dihydro-1-hydroxy-2-iminopyrimidine component and a penetration-enhancing vehicle are disclosed. The vehicle comprises a binary combination of a C.sub.3 -C.sub.4 diol or C.sub.3 -C.sub.6 triol and isocetyl alcohol polar lipid compound. The vehicle provides marked transepidermal and percutaneous delivery of the iminopyrimidine compound. These compositions, when applied topically, act to stimulate the growth of mammalian hair on the body.

Penetrating topical pharmaceutical compositions

Compositions for the transdermal delivery of buprenorphine comprising a safe and effective amount of buprenorphine in a carrier comprising:

Compositions for the transdermal delivery of pharmaceutical actives

Trienamide and tetraenamide compounds, and pharmaceutically-acceptable salts thereof, of the formula: ##STR1## wherein R is a straight or branched chain tri-unsaturated or tetra-unsaturated fatty acid amide having from 14 to 24 carbon atoms, exhibit anit-inflammatory and analgesic activity when administered to humans or lower animals.

Growing community of inventors

Wyoming, OH, United States of America

Gerald B Kasting