University of Missouri

Gerald Arthur

Charles W Caldwell, Jr

Raghuraman Kannan

Ajit Zambre

Charles William Caldwell

Mripen Chanda

Mythili Ramachandran

Nripen Chanda

Mythilil Ramachandran

An embodiment of the invention is a peptide comprising four domains, wherein domain I consists of thioctyl or monocytl, domain II consists of 2 to 3 positively charged amino acids selected from the group consisting of lysine and arginine, domain III consists of a dimeric ethylene unit; and domain IV comprises the peptide with SEQ ID No. 1 or a sequence having at least 90% identity to SEQ ID No. I. The peptide is preferably attached to a gold nanostructure, preferably a gold nanorod to provide an EFGR kit. An EFGR detection kit of the invention employs a gold nanostructure attached to a peptide sequence, the peptide sequence includes a binding sequence with an affinity toward EGFR, a ligand bound to gold atoms of the nanorod, a positively charged amino acid that maintains activity of the binding sequence, and a unit that increases hydrophilicity of the peptide sequence.

Peptide with gold binding and EGFR receptor affinity and same attached to gold nanostructure

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Rocheport, MO, United States of America

Gerald Arthur