Ge Healthcare UK Limited

Global Life Sciences Solutions Operations UK Ltd

Bayerische Motoren Werke Aktiengesellschaft

University of Warwick

Compound Semiconductor Applications Catapult Limited

Geraint Seymour

Peter James Tatnell

Stevan Paul Tortorella

Cheryl Louise Potts

Alan Stuart Pierce

Neil John Williams

Samantha Jane Ogden

Michael John Smith

Jeffrey Kenneth Horton

Christopher Burrows

Simon Laurence John Stubbs

Michael Kenneth Kenrick

Richard Martin West

Leonard Goren

Alison Myfanwy Wakefield

Navin Deepal Pathirana

Aidan Paul Vaughan

Martin David James

Nina Moran

Jared William Harris Evans

David Powell

Robert William Richardson

Phil Mawby

Sean Robert Sweeney

Ashley Edward Bryant

David Bock

Christian Burton

Alejandro Villarruel-Parra

Jarred William Harris Evans

Disclosed is a microfluidic device including a reagent supply apparatus comprising: a solid supportformed preferably from cellulose fibrous material having a porosity which allows liquid flow through the material; at least one generally dry reagentstored on a surface of the support at a regent location or locations; the support further being suitable for storing biological sample materialin a dry state at a sample location or locations, spaced from the reagent location or locations.

Microfluidic devices and arrangements for supplying such devices with reagents and biological samples

A biological sample holder for holding a solid phase sample, including a handle, and a seal area suitable for being received in an opening of a sample receiving chamber of a cassette, mountable to a sample analysis instrument. The holder further includes a stem connected to the seal and a sample retainer connected to the stem for retaining solids in the retainer, the sample retainer including a perforated wall region for allowing fluids to pass through the wall but preventing the solid phase sample from passing through the wall.

Sample holder for analysis of solid biological samples

The present invention relates to the field of nucleic acid collection and storage, and in particular to the collection and long-term storage of nuclei. The invention provides a device and method which can be used to capture and store nuclei at ambient temperatures allowing the subsequent isolation of nucleic acids by passive washing with a wash buffer. The present invention also provides a kit including the device of the invention suitable for carrying out the method of the invention.

Device and method for cell nuclei preparation

A microfluidic deviceis disclosed comprising a bodyincluding a biological sample S and/or reagent R receiving slot. The sample and reagent are carried on a solid support. The deviceincludes two punch assembliesfor removing portions of the solid supportand delivering them, together with the sample and/or reagent(s), to a receiving chamberfor subsequent processing. The device can be used for various assays including those which require just the addition of water in the reaction chamber with no pre-treatment of sample prior delivery into the chamber.

Microfluidic devices and arrangements for introducing reagents and biological samples to such devices

Embodiments of the present invention relate to a filtration device and method for filtering liquids. In conventional devices, a liquid is placed in a vial, and a plunger, having a filter membrane located at one end, is depressed into the vial, causing the liquid to pass through the filter membrane into the interior of the plunger, where it is stored until required for further processing. However, such plungers are typically made of a plastics material. It is undesirable to store the filtered liquid in contact with plastics for extended periods of time, as contaminants may leach from the plastics material into the sample. In embodiments of the present invention, a filtrate receptacle made from a different material to the plunger, such as a glass material, is located in the interior of the plunger and the filtered liquid collected in the filtrate receptacle after passing through the filter membrane. This allows the filtered liquid to be held isolated from the plastics material, thereby protecting it from contamination.

Filtration device and method

A controlled transfer biological sample material collection device is disclosed which includes a body and a sample collection member for collecting the biological sample material, the body housing a sample storage medium for generally dry storage of the biological material, the collection member being moveable from an exposed position where collection of a biological sample is possible, to a transfer position which effects transfer of at least a portion of the collected sample to said medium. The body of the device slideably supports the sample collection member, and the body or collection member includes a ramp-like projection portion operable to force the collection member into the transfer position against the medium and to effect the transfer as the collection member slides within the body.

Controlled transfer biological sample collection devices and methods of using such devices

The present invention provides a device comprising: a housing comprising a first opening for connecting to a liquid source, a second opening for connecting with an apparatus for drawing in and expelling liquid, and a valve means comprising a filter carrier and a filter, the filter carrier supporting the filter and being movable within the housing; wherein the valve means permits liquid that is drawn into the housing from the liquid source by the apparatus to enter the apparatus by bypassing the filter but which forces liquid that is subsequently pushed from the apparatus through the second opening into the housing to be filtered through the filter.

Continuous use syringe filter

A controlled transfer biological sample material collection device is disclosed which comprises: a body; and a sample collection member for collecting the biological sample material (not shown), the body housing a sample storage medium for generally dry storage of the biological material, the collection member being moveable from an exposed position (shown in FIG.) where collection of a biological sample is possible, to a transfer position (shown in FIG.) which effects transfer of at least a portion of the collected sample to said medium. The device is characterized in that the body slideably supports the sample collection member, and in that the body or collection member include a ramp-like projection portion (FIG.) operable to force the collection member into the transfer position against the medium and to effect said transfer as the collection member slides within the body.

Embodiments of the present invention relate to a filtration device for use in filtration of a liquid, and disclose: a liquid receptacle having an open end and a closed end; a plunger body moveable at least partially within the liquid receptacle along an axis said axis extending between the open and closed ends, said plunger including a filtrate chamber in fluid communication with the liquid receptacle via a fluid filtering path and a filter disposed in the filtering path, and the device further including a slidable seal for inhibiting or preventing fluid flow across the seal during said plunger movement; wherein said seal includes a first skirt depending from the plunger at one end of the first skirt, said first skirt having an outer surface which in use slidably and sealingly abuts the vial, and having, at least in an uncompressed state, a generally annular separation between the skirt and the plunger body, which separation extends generally parallel to the axis. A second skirt, overlapping the first skirt, is disclosed also.

Filter vial compressor

Growing community of inventors

Cardiff, United Kingdom

Geraint Seymour