Sebia

Georges Nouadje

Frédéric Robert

Laurent Vincent

Thierry Ligneel

Frederic Robert

Disclosed is a method for analyzing biological samples by immunofixation electrophoresis which involves immunodisplacement of target component(s) that may be present in the assayed biological sample, the target component(s) amounting to interfering component(s) when interpretation of the immunofixation results is considered. The immunodisplacement is carried out on an electrophoretic support that is preferably a gel, as defined herein. Accordingly, the invention provides IFE using an antibody or antibodies which is(are) modified (modified antibody) to bear additional negative electric charges, the modified antibody(ies) having antigenic specificity for a predetermined target immunoglobulin.

Immunofixation electrophoresis method with target component on-gel immunodisplacement

Capillary electrophoresis systems, reagents, and processes for analyzing a sample which includes at least one protein constituent are disclosed. The processes involve introducing the sample into a capillary tube containing a buffer system, wherein said buffer system includes at least one additive having a hydrophobic interaction with said at least one protein constituent and providing said at least one protein constituent with at least one negative charge thereby modifying the electrophoretic mobility.

Capillary electrophoresis systems and additives

The invention concerns a composition for use in a process for separating the constituents of a sample by electrophoresis on an electrophoresis support, comprising one or more ionic compounds which, on applying an electric field to an electrophoresis support having negative surface charges, causes hydration of the zone for loading the sample to be separated when said zone carries a compression mark resulting from loading the sample.

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Evry, France

Georges Nouadje