Entelos, Inc.

Georges Natsoulis

Stuart Tugendreich

Cecelia Pearson

Michael Furness

Kurt Jarnagin

Barrett P Eynon

Kurt Jarnigan

Mark Fielden

Kyle Kolaja

The present invention includes methods and apparatus for use in rapid testing for and prediction of a PPAR&#x3b1; response (i.e. a response similar to that of PPAR&#x3b1; agonists). The invention includes a PPAR&#x3b1; response signature comprising a set of twenty genes. The invention discloses methods whereby the differential expression of the genes of the PPAR&#x3b1; response signature may be used to predict whether a compound will induce a PPAR&#x3b1; response in a test subject.

Peroxisome proliferation activated receptor alpha (PPAR&#x3b1;) signatures

The invention discloses reagent sets and gene signatures for predicting onset of renal tubule injury in a subject. The invention also provides a necessary set of 186 genes useful for generating signatures of varying size and performance capable of predicting onset of renal tubule injury. The invention also provides methods, apparatuses and reagents useful for predicting future renal tubule injury based on expression levels of genes in the signatures. In one particular embodiment the invention provides a method for predict whether a compound will induce renal tubule injury using gene expression data from sub-acute treatments.

Reagent sets and gene signatures for renal tubule injury

Disclosed is a method for predicting the biological activity of a compound by the similarity of its drug signature score to the scores of a plurality of known drug signatures.

Signature projection score

The present invention provides methods and compositions for use in rapid test or prediction of the propensity of a test compound to induce cholesterol reduction in a subject. The invention also includes a cholesterol reduction signature as well as the method of deriving such signature.

Cholesterol reduction signature

The present invention provides methods and compositions for use in rapid test or prediction of the propensity of a test compound to induce cholestasis in a subject. The invention also includes a Cholestasis signature database as well as the method of deriving such database.

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Kensington, CA, United States of America

Georges Natsoulis