Rhone-Poulenc S.a.

Georges Jolles

Gerard Ponsinet

Naphthacene derivatives of the formula: ##STR1## wherein each of R.sub.1 and R.sub.2 represents an oxygen atom or a group of the formula ##STR2## and R.sub.3 represents hydrogen, or an alkyl, alkanoyl, thioalkanoyl, aryl, aroyl, carbamoyl, thiocarbamoyl, methylthiocarbamoyl or amidino group, these groups being optionally substituted, and R.sub.4 represents hydrogen, or R.sub.3 and R.sub.4 together with the nitrogen atom to which they are attached represent piperazin-1-yl which carries on the second nitrogen atom an optionally substituted alkyl group, particularly 4-methoxy-5,12-dioxo-6,9,11-trihydroxy-7-(2,3,6-0-tridesoxy-3-amino-1-L-ly xohexosyl)-9-(1-formylhydrazono-ethyl)-5,7,8,9,10,12-hexahydro-naphthacene, and non-toxic salts thereof, posses anti-tumour properties.

Naphthacene pharmaceutical compositions and method of use

Antibiotics 20,798 RP and 27,706 RP of the general formula: ##SPC1## (wherein R represents a hydrogen atom or a hydroxy group) or acid addition salts thereof are prepared by reduction of a corresponding compound wherein the --CHOH--CH.sub.2 --R group is replaced by ##EQU1## The antibiotics of general formula I have valuable anti-tumour properties; that wherein R is hydroxy (27,706 RP) is new.

Antibiotic 27,706 RP and salt thereof

Naphthacene derivatives of the formula: ##SPC1## Wherein each of R.sub.1 and R.sub.2 represents an oxygen atom or a group of the formula ##EQU1## and R.sub.3 represents hydrogen, or an alkyl, alkanoyl, thioalkanoyl, aryl, aroyl, carbamoyl, thiocarbamoyl, methylthiocarbamoyl or amidino group, these groups being optionally substituted, and R.sub.4 represents hydrogen, or R.sub.3 and R.sub.4 together with the nitrogen atom to which they are attached represent piperazin-1-yl which carries on the second nitrogen atom an optionally substituted alkyl group, particularly 4-methoxy-5,12-dioxo-6,9,11-trihydroxy-7-(2,3,6-O-tridesoxy-3-amino-1-L-ly xohexosyl)-9-(1-formylhydrazono-ethyl)-5,7,8,9,10,12-hexahydro-naphthacene, and non-toxic salts thereof, possess anti-tumour properties.

Naphthacene derivatives

Naphthacene derivatives of the formula: ##SPC1## Wherein each of R.sub.1 and R.sub.2 represents an oxygen atom or a group of the formula ##EQU1## and R.sub.3 represents hydrogen, or an alkyl, alkanoyl, thioalkanoyl, aryl, aroyl, carbamoyl, thiocarbamoyl, methylthiocarbamoyl or amidino group, these groups being optionally substituted, and R.sub.4 represents hydrogen, or R.sub.3 and R.sub.4 together with the nitrogen atom to which they are attached represent piperazin-1-yl which carries on the second nitrogen atom an optionally substituted alkyl group, and non-toxic salts thereof, possess anti-tumor properties.

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Sceaux, France

Georges Jolles