Laboratoires Pos

Laboratoirs Alcon S.a.

Georges De Burlet

Guy Andermann

Michel Dietz

Jacques Himber

Joseph Spittler

Gerard LeClerc

Gerard Leclerc

Catherine Cannet

Beatrice Ruhland

Mohammed Bouzoubaa

Compounds which enhance the efficiency of the corneal endothelial fluid pump thereby promoting normal corneal function and deturgescence of swollen corneas, and methods for the compounds' synthesis are described. In addition, surgical irrigating solutions which include one or more of the compounds are discussed along with methods for their use.

Compounds having GABA like activity, and use of same in tissue

A tissue irrigating solution useful for irrigating animal tissue, such as ocular tissue and neuro tissue, during surgery, contains sodium, potassium, magnesium calcium chloride, and bicarbonate ions as well as dextrose, glutathione, and gamma-amino butyric acid (GABA) or functional analogue(s) of GABA, or a mixture of GABA and such analogue(s) in proportions consistent with the osmotic stability and continued metabolism of the tissue cells. The irrigating solution is prepared by mixing a first basic solution which provides the bicarbonate and a second acidic solution which provides the calcium, magnesium, dextrose and glutathione. The first and second solutions may be stored as stable, sterile solutions for extended periods of time and mixed within 24 hours of use.

Two part tissue irrigating solution

Glaucoma can be treated by the application to the eye of a physiologically active amount of a compound of the formula ##STR1## in which: each of R.sub.3 and R.sub.4 is selected from hydrogen, and alkyl, alkenyl and cycloalkyl radicals, or R.sub.3 and R.sub.4 together with the carbon between them are a cycloalkylidene radical,

Ethers and oxime ethers of alkylamino alcohols as medicaments and novel

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Beblenheim, France

Georges De Burlet