Massachusetts Institute of Technology

Ric Investments, Inc.

George Zonios

Michael S Feld

Irving Itzkan

Lev T Perelman

Vadim Backman

Ramasamy Manoharan

Uday S Shankar

Vijay Kumar Iyer

The present invention relates to systems and methods for measuring one or more physical characteristics of material such as tissue using optical radiation. The system can use light that is scattered by a tissue layer to determine, for example, the size of nuclei in the tissue layer to aid in the characterization of the tissue. These methods can include the use of fiber optic devices to deliver and collect light from a tissue region of interest to diagnose, for example, whether the tissue is normal or precancerous.

Method for measuring tissue morphology

A method for calibrating a pulse oximeter device and an apparatus incorporating the method and a system for utilizing the method. The method is based on modeling light propagation in tissue at two wavelengths, typically, one in the red and one in the infrared range of the spectrum. A formula is derived relating the arterial oxygen saturation to a ratio R commonly measured by standard pulse oximeters. A specific parameter is identified and utilized in the calibration of the oximeter. This parameter is formulated in terms of the DC signals measured by the pulse oximeter at the two wavelengths. An empirical method for estimating this parameter based on experimental data is also described.

Adaptive calibration for pulse oximetry

Measuring tissue morphology

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Ioannina, Greece

George Zonios