University of California

Microsemi Corporation

George Y Liu

Victor Nizet

Yongcheng Song

Eric Oldfield

Shawn Anthony Fahrenbruch

The disclosure provides compounds and methods to treat a microbial or a bacterial pathogenesis, and demonstrates that thepigment is a virulence factor and potential novel target for antimicrobial therapy.

Antimicrobial compositions for treating microbial infections

The disclosure provides a molecular genetic approach of targeted mutagenesis and heterologous expression, coupled with in vitro and in vivo models of bacterial pathogenesis, to demonstrate that thepigment is a virulence factor and potential novel target for antimicrobial therapy.

Antimicrobial therapy for bacterial infections

A low voltage drop unidirectional electronic valve constituted of: a first terminal; a second terminal; a first electronically controlled switch coupled between the first terminal and the second terminal; and a first charge pump arranged to close the first electronically controlled switch when the voltage potential at the first terminal is greater than the voltage potential at the second terminal by a first value. The first charge pump is arranged in a closed loop with the first electronically controlled switch so as to continuously maintain the voltage potential at the first terminal greater than the voltage potential at the second terminal by the first value.

Low voltage drop closed loop unidirectional electronic valve

The disclosure provides compounds and methods to treat bacterial pathogenesis, and demonstrates that thepigment is a virulence factor and potential novel target for antimicrobial therapy.

Growing community of inventors

Irvine, CA, United States of America

George Y Liu