Glaxo Wellcome Inc.

Burroughs Wellcome Co.

Other

George Walter Koszalka

Thomas A Krenitsky

Susan Mary Daluge

Stanley Dawes Chamberlain

Charlene L Burns

Janet L Rideout

Jeffrey H Tidwell

Devron R Averett

Gerald Wolberg

Joel Van Tuttle

Nanine Agneta Vandraanen

Leroy B Townsend

John Charles Drach

Martin J Slater

George Andrew Freeman

Sylvia M Tisdale

Wayne H Miller

Joseph H Chan

The present invention relates to benzimidazole derivatives and their use in medical therapy particularly for the treatment or prophylaxis of restenosis.

Therapeutic compounds

Benzimidazole derivatives for the treatment of viral infections

The present invention relates to benzimidazole derivatives and their use in medical therapy particularly for the treatment or prophylaxis of virus infections such as those caused by herpes viruses. The invention also relates to the preparation of the benzimidazole derivatives and pharmaceutical formulations containing them.

L-benzimidazole nucleosides

Antiviral benzimidazole nucleoside analogues and a method for their

Antiviral benzimidazole nucleoside analogues and method for their

6-Alkoxy derivatives of Ara-G, and pharmaceutically acceptable esters thereof, are described as being useful in tumor therapy. Novel pharmaceutically acceptable esters, their preparation and pharmaceutical formulations containing them are also disclosed.

Tumor treatment with arabinofuranosyl purine derivatives

6-Alkoxy derivatives of Ara-G, and pharmaceutically acceptable esters thereof, are described as being useful in tumour therapy. Novel pharmaceutically acceptable esters, their preparation and pharmaceutical formulations containing them are also disclosed.

Therapeutic methods for using ARA-G derivatives

2',3'-dideoxy-3'-fluoro-purine ribonucleosides

Therapeutic nucleosides

A method for treating HIV infections comprising administering a composition whose active ingredient is 2',3'-dideoxy-3'-fluoro-5'-chlorouridine.

Method of treating HIV infections with

The present invention relates to certain 2',3'-dideoxynucleosides and pharmaceutically acceptable derivatives thereof, methods for preparing them, their use in the treatment and prophylaxis of viral, especially retroviral, infections, and pharmaceutical formulations containing them.

Methods of treating hepatitis B virus infection with therapeutic

Method for treating T-cell lymphoblastic leukemia with ara-G nucleoside

A method for treating two specific protozoal infections, Trichomonas vaginalis and Giardia lamblia, comprising the administration to a mammal in need thereof one of the following purine nucleosides:

Method for the treatment of protoza infections with 2.sup.1

This invention relates to certain 6-substituted 2',3'-dideoxypurine nucleosides and pharmaceutically acceptable derivatives thereof and their use in the treatment of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infections. Also provided are pharmaceutical formulations and processes for the production of the compounds of the invention.

This invention relates to certain derivatives of 2', 3'-dideoxycytidine and their use in medical therapy particularly in the treatment of HIV infections. Also provided are pharmaceutical formulations and processes for the manufacture of the compounds according to the invention.

Growing community of inventors

Chapel Hill, NC, United States of America

George Walter Koszalka