Oxford University Innovation Limited

Thomas Jefferson University

Actelion Pharmaceuticals Ltd

United Therapeutics Corporation

Isis Innovation Limited

George W J Fleet

Raymond A Dwek

Frances M Platt

Terry D Butters

Timothy Michael Block

Gary S Jacob

Nicole Zitzmann

Donald H Picker

Michael Glen Orchard

Anand Mehta

Terence D Butters

David Durantel

Sandra Carrouee

David Scott

Malcolm Finn

Thomas Krūlle

Pharmaceutically active piperidine derivatives

Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C-Calkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.

Long chain N-alkyl compounds and oxa-derivatives thereof

A compound of Formula I are provided: wherein R is: Ris a substituted or unsubstituted alkyl group; Ware independently selected from hydrogen, substituted or unsubstituted alkyl groups, substituted or unsubstituted haloalkyl groups, substituted or unsubstituted alkanoyl groups, substituted or unsubstituted aroyl groups, or substituted or unsubstituted haloalkanoyl groups; Xare independently selected from H, NO, N, and NH; Y is absent or is a substituted or unsubstituted C-alkyl group, other than carbonyl; Z is selected from a bond or NH, provided that when Z is a bond, Y is absent, and provided that when Z is NH, Y is a substituted or unsubstituted C-alkyl group, other than carbonyl. Also provided are D-arabinitol compounds, methods for preparing such compounds and compositions of such compounds, and methods of using such compounds.

Deoxynojirimycin and D-arabinitol analogs and methods of using

Long chain n-alkyl compounds and oxa-derivatives thereof

Derivatives of bis-(1,3-dihydroxy-prop-2-yl)amine are disclosed, together with the use of such derivatives and of bis(1,3-dihydroxy-prop-2-yl)amine itself in the preparation of polymers, in particular dendrimers. Some of the derivatives may be useful as non-ionic surfactants.

Bis(1,3-dihydroxy-prop-2-yl) amine and derivatives thereof in the manufacture of polymers

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Oxford, United Kingdom

George W J Fleet