University of Washington

The United States of America, As Represented by the Secretary, Department of Health and Human Services

George Ueda

Jorge Fallas

David Baker

Neil P King

Daniel Ellis

William H Sheffler

Vanessa Nguyen

Barney S Graham

Masaru Kanekiyo

Lance Joseph Stewart

Lauren Carter

Brooke Fiala

Rebecca A Gillespie

Rashmi Ravichandran

Una Nattermann

Jing Yang Wang

Seyhan Boyoglu-Barnum

Nanoparticles and vaccines containing these nanoparticles that elicit an immune response against hemagglutinin (HA) proteins from a broad range of influenza viruses are provided. The nanoparticles are made from self-assembling proteins, at least one of which is joined to an immunogenic portion of an influenza HA protein. This immunogenic portion is displayed on the nanoparticle surface, making the nanoparticles useful for vaccinating subjects against influenza virus.

Nanoparticle-based influenza virus vaccines and uses thereof

Described herein are polypeptides capable of self-assembling to form homo-oligomers, and methods for designing such polypeptides.

Computational design of self-assembling cyclic protein homo-oligomers

Nanostructures and nanostructure-based vaccines that display antigens capable of eliciting immune responses to infectious agents such as bacteria, viruses, and pathogens are provided. Some vaccines are useful for preventing or decreasing the severity of infection with an infectious agent, including, for example and without limitation, lyme disease, pertussis, herpes virus, orthomyxovirus, paramyxovirus, pneumovirus, filovirus, flavivirus, reovirus, retrovirus, meningococcus, or malaria. The antigens may be attached to the core of the nanostructure either non-covalently or covalently, including as a fusion protein or by other means. Multimeric antigens may optionally be displayed along a symmetry axis of the nanostructure. Also provided are proteins and nucleic acid molecules encoding such proteins, vaccine compositions, and methods of administration.

Self-asssembling nanostructure vaccines

Growing community of inventors

Seattle, WA, United States of America

George Ueda