Threshold Pharmaceuticals, Inc.

Horizon Pharma Usa, Inc.

La Jolla Pharma, LLC

La Jolla Pharmaceutical Company

Horizon Therapeutics, LLC

George Tidmarsh

Jerry Xu

Lakhmir S Chawla

Mark D Matteucci

Photon Rao

Barry L Golombik

Puneet Sharma

Steve Ching Tsung Chen

The present disclosure relates to the use of angiotensin II, angiotensin III, or angiotensin IV in therapeutic methods for the treatment of hypotension, especially catecholamine-resistant hypotension.

Methods for administering angiotensin II

Methods for treating hypotension in a patient that has received an ACE inhibitor by administering angiotensin II

The present disclosure relates to the use of angiotensin II in therapeutic methods for the treatment of renal failure, especially renal failure associated with cirrhosis.

Compositions and methods for treating renal failure

Methods for the treatment of cancer are described. In particular, methods for treatment of cancer comprising administration of glufosfamide alone or in combination with another anticancer agent are disclosed.

Anti-cancer therapies

Stable pharmaceutical compositions of famotidine and ibuprofen in a single unit dosage form are disclosed herein. The compositions comprise a famotidine core having a reduced or minimal surface area surrounded by a layer of ibuprofen. In some embodiments, the ibuprofen is in direct physical contact with the famotidine.

Stable compositions of famotidine and ibuprofen

A method for administration of ibuprofen to a subject in need of ibuprofen treatment is provided, in which an oral dosage form comprising a therapeutically effective amount of ibuprofen and a therapeutically effective amount of famotidine is administered three times per day.

Methods and medicaments for administration of ibuprofen

The level of one or more glucose transporters in a sample containing cancer cells is measured and compared to a reference value to determine whether the cancer is susceptible to treatment with an anti-cancer agent comprising glucose or glucose analog that is transported into the cancer by a glucose transporter.

Method for determining susceptibility of tumor to treatment with anti-neoplastic agent

Methods and compositions are provided for the treatment of cancer that take advantage of the increased uptake of glucose-anti-neoplastic agent conjugates in cancer cells relative to normal cells.

Compositions and methods for treating cancer

Methods are provided for cancer and pre-cancer detection by increased uptake of fluorophore glucose or deoxyglucose conjugates in cancerous and pre-cancerous cells relative to normal cells.

Growing community of inventors

Portola Valley, CA, United States of America

George Tidmarsh