Imperial College Innovations Limited

3i Research Exploitation Limited

George T Stevenson

This invention is directed to intermediates for use in the preparation of chimeric antibodies and synthetic antibody derivatives. The intermediates are open- or closed-hinge Fc fragments that have at least one alkylated external sulphydryl group. The invention is also directed to processes for making such intermediates, chimeric antibodies or synthetic antibody derivatives produced from the intermediates, and to methods of treating B-cell Lymphoma by administering chimeric antibodies or synthetic antibody derivatives produced using the intermediates of the invention.

Processes and intermediates for synthetic antibody derivatives

Synthetic antibody derivatives having at least two F regions covalently linked so as to enhance Fc activity for example effector recruitment. The use of such derivatives in the treatment of conditions where killing of cells is required for example cancer therapy. Methods for the preparation of derivatives are also described.

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Southampton, United Kingdom

George T Stevenson