Merck + Co., Inc.

Pharmacia Corporation

Monsanto Company

Isp Investments Inc.

George T Colegrove

Thomas A Lindroth

John Flanagan

Thierry Nivaggioli

George T Veeder

Kenneth S Kang

Walter Gregory Rakitsky

Kenneth Clare

John L Holahan

Robert Raczkowski

William Scott Bousman

Monica A Garcia

Barbara A Smith

A film coated tablet wherein the tablet is film coated with a gellan gum coating composition containing gellan gum, a plasticizer, and a disintegration aid. Optionally a slip enhancer is added to the composition. A method for coating a tablet with the gellan gum composition wherein the composition is applied as a solution. A method of administering the gellan gum film coated tablet as a pharmaceutical.

Gellan gum tablet film coating

A pharmaceutical composition comprising a tablet having a dried coating thereon, wherein the composition has a total weight of about 100 mg to about 1.5 g, the dried coating comprises about 0.025% to about 10% by weight of the total composition, and gellan gum is the principal component of the dried coating

Gellan gum tablet coating

A gel system comprising propylene glycol alginate and basic aluminum acetate salt. Also, disclosed is a personal care formulation comprising a room deodorant gel employing said gel system.

Propylene glycol alginate gels

A stable, non-aqueous gum slurry which can be readily pumped or metered into a given formulation without swelling the gum or causing an excessive increase in viscosity, comprising a gum, a low molecular weight liquid polyethylene glycol as a non-solvent, and dissolved therein, a high molecular weight, solid polyethylene glycol as viscosifier.

Gum slurries

The present invention is directed towards biopolymer salts and biopolymer compositions comprising a biopolymer salt having an endotoxin content less than about 100 endotoxin units per gram. Because of their low endotoxin content, the biopolymer salts and biopolymer compositions of this invention may be administered parenterally to a patient. The present invention is also directed to methods of preparing the compositions of this invention.

Biopolymer salts with low endotoxin levels, biopolymer compositions thereof and methods of making the same

A tablet coating comprising gellan gum is disclosed along with a process which comprises admixing gellan gum and water under effective shear conditions to prepare an aqueous gellan gum coating composition thereof whereby the aqueous gellan gum coating composition is applied in an adherent fashion to a placebo or a tablet containing a pharmaceutical to form a gellan gum coated placebo or gellan gum coated active drug.

This invention relates to coatings employed to coat medicinal tablets. Such tablets include but are not limited to small pellet(s) of medication to be taken orally. In particular this invention relates to the use of alginates and/or gellan gum, mixtures thereof and the like as tablet coatings. More in particular, this invention relates to the use of alginate and gellan gum as tablet coatings for tablets which are useful for humans including coating(s) on medicinal tablets and to a process for making such coatings.

Alginate and gellan gum as tablet coating

Acid-stable and cationic-compatible reticulated bacterial cellulose compositions, containing co-agents and/or cationic surfactants, that are useful rheological modifying agents and stabilizing agents for suspensions, emulsions and foams, and their methods of preparation are disclosed.

Acid-stable and cationic-compatible cellulose compositions and methods of preparation

Sustained release tablet comprising a microbially produced alginate-type polysaccharide and an active ingredient to be delivered in controlled fashion.

Sustained release tablets containing alginate

Polysaccharide fibers are produced by hot extrusion of a gelling polysaccharide into air or a gelling salt bath. Optionally, other polysaccharides, including non-gelling types, may be co-extruded with the gelling polysaccharide. The fibers are useful for the production of wound dressings and catamenial devices, and many other devices.

Process for making polysaccharide fibers

Low viscosity heteropolysaccharides, e.g., zanthan gum, S-194, and guar gum, are disclosed. These gums are especially useful in preparing herbicidal compositions.

Low viscosity heteropolysaccharides

Low viscosity heteropolysaccharides, e.g., xanthan gum, S-194, and guar gum, are disclosed. These gums are especially useful in preparing herbicidal compositions.

Solid, herbicidal complexes

Bipyridinium quaternary salt compositions are prepared which are dry, free-flowing, wettable powders. The solid compositions are complexes of the bipyridinium salts and algin.

Solid, herbicidal bipyridinium quaternary salt compositions

Derivatized anionic gums and compositions thereof are disclosed. The gum derivatives are prepared by reacting non-derivatized gum with quaternary ammonium compounds in an amount equal to or greater than the stoichiometric amount required for complete derivatization. The derived gums are soluble in organic solvents.

Quaternary ammonium salts of anionic gums

Viscous solutions of NMP are described which comprise up to about 90% NMP. The viscosifying agent is rhamsan gum.

Growing community of inventors

San Diego, CA, United States of America

George T Colegrove