Cohesion Technologies, Inc.

George T Coker, Iii

Woonza M Rhee

Donald G Wallace

Jacqueline Anne Schroeder

Gregory M Cruise

Marcee M Maroney

Olof Mikael Trollsas

A method is provided for the rapid formation of a biocompatible gel, and may be carried out in situ, i.e., at a selected site within a patient's body. The method involves admixing a biocompatible crosslinking component A having m sulfhydryl groups wherein m&gE;2 and a biocompatible crosslinking component B having n sulfhydryl-reactive groups wherein n&gE;2 and m&plus;n>4, wherein the sulfhydryl-reactive groups are capable of covalent reaction with the sulfhydryl groups upon admixture of the components under effective crosslinking conditions to form a gel in less than one minute. Suitable reaction conditions for carrying out the crosslinking reaction will depend on the particular components and the type of reaction involved; that is, the &ldquo;effective crosslinking conditions&rdquo; may involve reaction in bulk or in a solvent, addition of a base, and/or irradiation of the admixture in the presence of a free radical initiator. Exemplary uses include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury. Reactive gel-forming compositions and systems are also provided.

Rapid-gelling biocompatible polymer composition and associated methods of preparation and use

This invention relates generally to two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired. In particular, they are useful as tissue sealants, in promoting hemostasis, for drug delivery, in effecting tissue adhesion, in providing tissue augmentation, and in the prevention of surgical adhesions.

Rapid gelling biocompatible polymer composition

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Castro Valley, CA, United States of America

George T Coker, Iii