University of Ottawa

Dalhousie University

Dianovix, Inc.

Aegera Therapeutics, Inc.

George S Robertson

Robert G Korneluk

Alexander E MacKenzie

Martin Holcik

Natalie Roy

Virender Bhan

Andrea Hebb

Handunkutti Pathirannehalage Vasantha Rupasinghe

Daigen Xu

Stephen J Crocker

John W Gillard

Katsu Tamai

Craig Moore

Handunkutti Pathirannehalage Rupasinghe

Described herein are phenolic compositions derived from apple skins. In particular, described herein are flavonoid-rich fractions derived from apple skin extract. The compositions are useful in the prevention and treatment of conditions associated with oxidative stress and/or inflammation, including certain neurodegenerative diseases. Methods of producing the compositions are also described.

Phenolic compositions derived from apple skin and uses thereof

Disclosed is a method of determining interferon responsiveness in a patient suffering from multiple sclerosis. The method comprises determining an amount of a XAF-1 gene expression level in a blood sample, which is obtained from the patient undergoing interferon therapy. The amount of the XAF-1 gene expression level in the blood sample is then correlated with the responsiveness of the patient to the interferon.

Diagnostic marker for interferon responsiveness in multiple sclerosis

Disclosed herein is a method for differentiating between multiple sclerosis subtypes in a patient. The method comprises a) determining an amount of an IAP gene expression level in a blood sample obtained from the patient; and b) correlating the amount of the IAP gene expression level in the blood sample with the presence of a multiple sclerosis subtype in the patient.

Method for differentiating between multiple sclerosis subtypes

The invention provides a novel NAIP nucleic and sequences. Also provided are anti-NAIP antibodies and methods for modulating apoptosis and detecting compounds which modulate apoptosis.

Use of neuronal apoptosis inhibitor protein (NAIP)

The invention provides NAIP nucleic acid and sequences. Also provided are anti-NAIP antibodies and methods for modulating apoptosis and detecting compounds which modulate apoptosis.

NAIP and IAP polypeptides prevent neuronal cell death caused by ischemia, neurodegenerative conditions, and axotomy. The invention provides methods for neuroprotection by the prevention of cell death and kits and methods for the identification of neuroprotective therapeutic compounds.

Methods for enhancing survival of a neuron

Therapeutic and drug screening methods for the treatment and prevention

Growing community of inventors

Halifax, Canada

George S Robertson