The United States of America, As Represented by the Secretary, Department of Health and Human Services

University of Cincinnati

George S Deepe

Errol Reiss

Timothy J Lott

Leonard W Mayer

Rosely M Zancope-Oliveira

The present invention provides the nucleotide sequence of the M antigen gene of, which is set forth in the Sequence Listing as SEQ ID NO:1, a nucleic acid having the nucleotide sequence complementary thereto, and nucleic acids having a nucleotide sequence which is substantially the same as the foregoing nucleotide sequences. The present invention also provides vectors and host expressions systems containing the foregoing nucleic acids, and isolated or recombinantly-produced antigens encoded by the foregoing nucleic acids. The present invention further provides antibodies generated against the foregoing antigens, and methods and kits for detecting a previous or currentinfection in a subject, and for diagnosing histoplasmosis.

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Terrace Park, OH, United States of America

George S Deepe