Exelixis, Inc.

George Ross Francis

Lisa C Kadyk

Timothy S Heuer

Kim Lickteig

Michael R Costa

David Andrew Ruddy

Lynn Margaret Bjerke

Garth Joseph McGrath

Steven Brian Gendreau

Emery G Dora, Iii

Daniel Tim Curtis

Michael Christopher Ellis

Sharmon Monique Nicoll

Human PIK4CA genes are identified as modulators of the RAC pathway, and thus are therapeutic targets for disorders associated with defective RAC function. Methods for identifying modulators of RAC, comprising screening for agents that modulate the activity of PIK4CA are provided.

PIK4CA as modifier of the Rac pathway and methods of use

Human MAPK genes are identified as modulators of the Rac, axin, and beta-catenin pathways, and thus are therapeutic targets for disorders associated with defective Rac, axin, and beta-catenin function. Methods for identifying modulators of Rac, axin, and beta-catenin, comprising screening for agents that modulate the activity of MAPK are provided.

MAPKs as modifiers of the rac, axin, and beta-catenin pathways and methods of use

Human MELK genes are identified as modulators of the RAC pathway, and thus are therapeutic targets for disorders associated with defective RAC function. Methods for identifying modulators of RAC, comprising screening for agents that modulate the activity of MELK are provided.

MELKS as modifiers of the Rac pathway and methods of use

The invention provides methods and compositions relating to pen polypeptides having pen-specific structure and activity, related polynucleotides and modulators of pen function. The invention provides isolated pen hybridization probes and primers capable of specifically hybridizing with natural pen genes, pen-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis (e.g. genetic hybridization screens for pen transcripts), therapy (e.g. pen inhibitors to modulate APP processing) and in the biopharmaceutical industry (e.g. as immunogens, reagents for screening chemical libraries for lead pharmacological agents, etc.).

Presenilin enhancers assays

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Pacifica, CA, United States of America

George Ross Francis