Sk&f Lab Co.

Smithkline Corporation

George R Wellman

Clifford S Labaw

Robert L Webb

Bing L Lam

Elvin L Anderson

Wilford L Mendelson

Joseph J Lewis

Walter W Holl

John J Filan

A process for preparing cimetidine by sulfur extrusion from N-cyano-N'-methyl-N'-[2-(5-methyl-4-imidazolylmethyldithio)ethyl]guanidine .

Use of

Disulfide intermediate for cimetidine

A new series of gold containing sugars having anti-arthritic activity are characterized by the presence of a bis[(triethylphosphine)aurio]sulfonium salt moiety at the 1-position of the glucopyranoside. The compounds are prepared by reacting a 1-S-triethylphosphinegold-1-thio-glucopyranoside with a triethylphosphinegold halide.

Bis[triethylphosphine)aurio]sulfonium sugars

New imidazolemethylphosphonium salts having a degradable group at the 2-position which are useful intermediates for preparing histamine H.sub.2 antagonists. This invention concerns the preparation of imidazolemethylphosphonium salts having no substituent at the 2-position by heating the compounds referred to above.

Process for preparing new imidazolemethylphosphonium salts

New imidazolemethylphosphonium salts having a degradable group at the 2-position which are useful intermediates for preparing histamine H.sub.2 antagonists.

Intermediates and processes useful for preparing medicinal agents

Imidazolemethylphosphonium salts

An improved process for the preparation of 4-(hydroxymethyl)imidazoles by reducing 4-imidazolecarboxylic acid esters using an alkali metal or calcium in liquid ammonia with an additional proton source provided during the reaction or upon workup.

Process for preparing 4-(hydroxymethyl)imidazole compounds

A process for preparing 5-(alkoxy- and aminoethylthio)methylthiazole compounds via displacement of the trisubstituted phosphonium group from 5-(trisubstituted phosphonium)methylthiazole compounds is disclosed.

Process for preparing 5-(alkoxy- and aminoethyl thio)methylthiazole

A method of preparing .alpha.,.beta.-epoxy ketones by reacting water-soluble .alpha.,.beta.-ethylenic ketones with sodium hypochlorite. Especially useful for preparing 3,4-epoxy-butanone.

Growing community of inventors

Warminster, PA, United States of America

George R Wellman