University of Washington

Other

Koninklijke Philips Corporation N.v.

Fred Hutchinson Cancer Center

Koninklijke Philips N.v., a Corporporation Organized and Existing Under the Laws of Kingdom of the Netherlands

George R Schade

Tatiana Khokhlova

Vera Khokhlova

Michael R Bailey

Adam D Maxwell

Wayne Kreider

Yak-Nam Wang

Oleg A Sapozhnikov

Ari Partanen

Navid Farr

Joo Ha Hwang

John R Chevillet

Donghoon Lee

Muneesh Tewari

Pavel Rosnitskiy

Petr V Yuldashev

An example method includes generating an acoustic ultrasound wave that is focused at a focal point. The method further includes sequentially directing the focal point upon distinct portions of an object to form respective shock waves at the distinct portions of the object. The method further includes, via the respective shock waves, causing the distinct portions of the object to boil and form respective vapor cavities. The method further includes causing substantially uniform ablation of a region of the object that comprises the distinct portions. The substantially uniform ablation is caused via interaction of the respective shock waves with the respective vapor cavities. An example ablation system and an example non-transitory computer-readable medium, both related to the example method, are also disclosed.

Boiling histotripsy methods and systems for uniform volumetric ablation of an object by high-intensity focused ultrasound waves with shocks

The present disclosure is directed to relates to systems and methods for evaluating tissue using high intensity focused ultrasound (HIFU) energy. In one embodiment, for example, a system for treating a patient comprises an ultrasound source configured to deliver HIFU energy to a target tissue mass of the patient and a function generator operably coupled to the ultrasound source for initiating a pulsing protocol for delivering the HIFU energy. The system further comprises a controller configured to perform operations comprising applying HIFU energy to induce cavitation in the target tissue mass and cause a biomarker to be released, comparing a baseline concentration of the biomarker from a first fluid sample to a concentration of the biomarker in a second fluid sample within 2 hours after applying HIFU, and repeating the applying and comparing until the concentration of the biomarker in the fluid sample falls below a threshold value.

Systems and methods for evaluating tissue of a subject

Transrectal ultrasound probe for boiling histotripsy ablation of prostate are presented herein. In one embodiment, a method for a transrectal ultrasound treatment uses high intensity focused ultrasound (HIFU). The method includes: generating a boiling histotripsy (BH) therapy ultrasound by a therapy transducer in a frequency range of 1 MHz to 2.8 MHz and a surface intensity range of 10 W/cm2 to 80 W/cm2. The therapy transducer may be about 50 mm long and about 35 mm wide. The method also includes applying the therapy ultrasound by directing ultrasound pulses having ultrasound shock waves to a target tissue at a focal depth of 2.5 cm to 5.5 cm; generating at least one μm-scale vapor bubble at a target region; growing the at least one vapor bubble to at least one mm-scale bubble; and mechanically disintegrating a surrounding tissue by interactions between mm-scale bubbles and the ultrasound shock waves within a pulse.

Transrectal ultrasound probe for boiling histotripsy ablation of prostate, and associated systems and methods

High intensity focused ultrasound systems for treating tissue are disclosed herein. A system of treating tissue in a patient in accordance with an embodiment of the present technology can include, for example, an ultrasound source having a focal region and configured to deliver high intensity focused ultrasound energy to a target site in tissue of the patient. The system can further include a controller operably coupled to the ultrasound source. The controller comprises a pulsing protocol for delivering the high intensity focused ultrasound energy with the ultrasound source to the target site. The controller is configured to cause the ultrasound source to pulse high intensity focused ultrasound waves to lyse cells in a volume of the tissue of the subject while preserving an extracellular matrix in the volume of the tissue exposed to the high intensity focused ultrasound waves.

High intensity focused ultrasound systems for treating tissue

Example embodiments of system and method for magnetic resonance imaging (MRI) techniques for planning, real-time monitoring, control, and post-treatment assessment of high intensity focused ultrasound (HIFU) mechanical fractionation of biological material are disclosed. An adapted form of HIFU, referred to as 'boiling histotripsy' (BH), can be used to cause mechanical fractionation of biological material. In contrast to conventional HIFU, which cause pure thermal ablation, BH can generate therapeutic destruction of biological tissue with a degree of control and precision that allows the process to be accurately measured and monitored in real-time as well as the outcome of the treatment can be evaluated using a variety of MRI techniques. Real-time monitoring also allow for real-time control of BH.

Method and system for MRI-based targeting, monitoring, and quantification of thermal and mechanical bioeffects in tissue induced by high intensity focused ultrasound

A method for using an extractor system to extract particulate material from a liquid tank includes inserting a first conduit into a liquid tank; inserting an outflow line into the liquid tank, the outflow line comprising one or more nozzles having a distal end; inserting an inflow line into the liquid tank, the inflow line comprising a collector having a distal end, the collector and the one or more nozzles being proximate each other; and operating the pump to pump liquid from an extractor tank through an outflow line out of the one or more nozzles to unsettle the particulate material, the particulate material drawn through the collector and the inflow line into the extractor tank without passing through the pump.

Garnet extraction system and method for using the same

Extractor tank for holding garnet extracted from a water jet cutter

Growing community of inventors

Seattle, WA, United States of America

George R Schade