Riptide Bioscience, Inc.

Technovax, Inc.

Fibralign Corporation

Leland Stanford Junior University

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Mannkind Corporation

George R Martin

Jesse M Jaynes

Jose M Galarza

Henry Wilfred Lopez

Clayton Yates

Charles Garvin

Michael V Paukshto

David Harwood McMurtry

Kathryn Wynne Woodburn

Tatiana Zaitseva

L Edward Clemens

John P Cooke

Mikhail Vitoldovich Paukshto

Helene Boigard

Andrea Leone-Bay

Chad C Smutney

Marshall L Grant

Gerald G Fuller

Yuri Alexandrovich Bobrov

Ngan Fong Huang

Udo Rudloff

Hector Munoz

Henry Willfred Lopez

David H Mcmurtry

Jose Galarza

Described herein are influenza virus-like particles (VLPs) that display on truncated, re-engineered or remodeled HA molecules on their surface. Also described are methods of making and using these VLPs.

Universal virus-like particle (VLP) influenza vaccines

Flavivirus virus-like particles (VLPs) are provided that display on their surfaces antigenic flavivirus proteins. The VLPs include at least one flavivirus structural protein and at least one non-structural flavivirus protein. A DNA construct that includes sequences encoding flavivirus viral proteins used to assemble the flavivirus VLP is also provided. A method of producing flavivirus VLPs by introducing one or more the DNA constructs into a host cell is also provided. An immunogenic composition that includes the flavivirus VLP is also provided.

Flavivirus and alpha virus virus-like particles (VLPS)

Aspects of the present invention relate to peptides having antimicrobial activity. In certain aspects, the invention relates to peptides having potent antimicrobial activity, broad-spectrum antimicrobial activity, and/or the ability to kill otherwise antibiotic-resistant microbes, or microbes protected by biofilms.

Antimicrobial peptides and methods of using the same

The present disclosure provides novel peptides that having immunomodulatory activities in vitro and in vivo. The peptides can include a particular striapathic region of alternating hydrophilic and hydrophobic modules that can adopt an amphipathic conformation under physiological conditions. This disclosure provides peptides that can specifically bind to key functional regions on one or more signaling proteins, particularly pro-inflammatory cytokines, macrophage inhibition proteins, and histone regulation proteins. This disclosure includes peptides that are sufficiently stable in the circulation to allow for intravenous administration. Pharmaceutical compositions including the subject peptides are also provided. The subject peptides find use in methods of modulating macrophage activity. In some cases, the peptide is a CD206-binding agent. Also provided are methods of treating a subject for a condition associated with chronic inflammation using the peptides and compositions of this disclosure.

Peptides having immunomodulatory properties

Described herein are flavivirus virus-like particles (VLPs) that display on their surfaces antigenic flavivirus proteins. Also described are methods of making and using these VLPs.

Flavivirus and alphavirus virus-like particles (VLPS)

Embodiments of the present invention relate to a therapeutic device (graft) comprising a collagen membrane having an aligned uniaxial or biaxial structure such that mammalian cells plated on the membrane align mainly along the direction of the collagen fibrils. In a further aspect, a graft comprising a substantially tubular body, wherein the body has an exterior surface, an interior surface, and at least one lumen extending therethrough such that a fluid flow through the lumen can direct mammalian cell migration. In a further aspect, mammalian cells or growth and angiogenic factors can be optionally attached to the exterior and/or interior surface of the substantially tubular body. In various aspects, the graft can be used as a vascular prosthesis, a stent, or a nerve regeneration scaffold. Methods of preparing and implanting same are also provided.

Graft for directed vascular and lymphatic regeneration and methods to guide endothelial cell assembly

Dry powder inhalable compositions and methods for using and making the compositions are disclosed for vaccinating a subject against disease. In particular, the compositions are inhalable dry powders useful for preventing and/or treating diseases caused by microorganisms, for example, microorganisms such as viral or bacterial pathogens, including, the influenza virus. In particular, the method comprises the administration of an inhalable composition comprising virus-like particles and/or specific protein/s or antigenic peptides, peptide fragments and/or derivatives thereof using a dry powder drug delivery system.

Inhalable vaccine compositions and methods

Aspects of the present invention relate to peptides having anti-inflammatory activity, compositions containing one or more of the peptides, and use of the peptides to treat conditions associated with excessive inflammation in animals, particularly humans and other mammals.

Peptides having anti-inflammatory properties

In general, the present invention is related to biopolymer and biocomposite materials and structures, and methods of making and using the same. In some embodiments, the present invention is directed to oriented collagen based biocomposite materials and structures, and methods of making.

Biocomposites and methods of making the same

Embodiments of the present invention relate generally to the field of tissue repair and regeneration. More specifically, embodiments of the present invention relate to medical devices, materials or constructs, such as conductive biocompatible polymers having one or more networks of metal nanowires that enhance tissue repair and regeneration using electromagnetic fields.

Conductive biopolymer implant for enhancing tissue repair and regeneration using electromagnetic fields

Antimicrobial peptides and methods of use thereof

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Rockville, MD, United States of America

George R Martin