University Of Pennsylvania

Monell Chemical Senses Center

University of Pa.

George R Huggins

George Preti

Winnifred B Cutler

Joseph Tonzetich

James G Kostelc

A novel method of determining the onset of the fertile period of a human female is disclosed comprising the step of monitoring the axillary secretions of said female during the course of her menstrual cycle to determine variations in the concentration of androstenol or dehydroepiandrosterone sulfate. A first significant increase in the concentration of either of those compounds following the cessation of menses is indicative of the onset of the fertile period. In each case, a follicular phase peak occurs which exceeds by at least twice the concentration of those compounds present at any other time during the menstrual cycle. As a result, the monitoring of these compounds may act as reliable indicators predicting the occurrence of ovulation in five to seven days, and/or indicating the onset of the fertile period at a time when appropriate contraceptive measures can still be taken to avoid pregnancy or sexual intercourse can promote fertility.

Axillary androstenol and dehydroepiandrosterone as fertile period onset

A novel method of determining the onset of the fertile period of a human female is disclosed comprising the step of monitoring the axillary secretions of said female during the course of her menstrual cycle to determine variations in the concentration of androstenol or dehydroepiandrosterone sulfate. A first significant increase in the concentration of either of those compounds following the cessation of menses is indicative of the onset of the fertile period. In each case, a follicular phase peak occurs which exceeds by at least twice the concentration of those compounds present at any other time during the menstrual cycle. As a result, the monitoring of these compounds may act as reliable indicators predicting the occurrence of ovulation in five to seven days, and/or indicating contraceptive measures can still be taken to avoid pregnancy or sexual intercourse can promote fertility.

Birth control method involving monitoring of axillary androstenol and

Method for determining the onset of the fertile period of a human female comprising the step of monitoring the axillary secretions of said female during the course of her menstrual cycle to determine variations in the concentration of androstenol or dehydroepiandrosterone sulfate. A first significant increase in the concentration of either of those compounds following the cessation of menses is indicative of the onset of the fertile period. In each case, a follicular phase peak occurs which exceeds by at least twice the concentration of those compounds present at any other time during the menstrual cycle. As a result, the monitoring of these compounds may act as reliable indicators predicting the occurrence of ovulation in five to seven days, and/or indicating the onset of the fertile period at a time when appropriate contraceptive measures can still be taken to avoid pregnancy or sexual intercourse can promote fertility.

Method for precisely ascertaining the time of ovulation by monitoring the concentration of alcohols in the range of C.sub.10 -C.sub.16, particularly dodecanol. A spike in the concentration of such compound(s) is indicative of time of ovulation.

Method detecting ovulation by monitoring dodecanol concentration in

A novel method is provided for precisely predicting and then ascertaining the time of ovulation by monitoring the mouth air of a female, a first peak after menses in the concentration of said volatile sulfur-containing compounds in said mouth air predicting ovulation by about 5 to 7 days, and a second increase thereafter being indicative of ovulation. Alternatively, a method is provided wherein TPTZ is utilized to sense secondary characteristics associated with the production of volatile sulfur compounds for the purpose of providing a simple colorimetric home test for determining the precise time of ovulation.

Method of predicting and determining ovulation by monitoring the

A method of monitoring the concentration of a given volatile organic compound, or of urea, or both, which compound(s) is commonly found in vaginal secretions is described as providing a reliable diagnostic indication of ovulation, and more particularly is described as providing a simple home-test method of predicting the onset of the fertile period, thereby increasing the reliability of the 'rhythm method' of birth control.

Method of predicting and detecting ovulation

A method of monitoring the concentration of a given volatile organic compound commonly found in vaginal secretions is described as providing a reliable diagnostic indication of ovulation, and more particularly is described as providing a simple home-test method of predicting the onset of the fertile period, thereby increasing the reliability of the 'rhythm metod' of birth control.

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Wallingford, PA, United States of America

George R Huggins