Zeneca Limited

Imperial Chemical Industries Limited

Astrazeneca Ab

Asterzeneca Ab

George R Brown

Michael J Smithers

Dearg Sutherland Brown

Andrew G Brewster

Keith Blakeney Mallion

Peter John Harrison, Deceased

Reginald Jessup

Alan Wellington Faull

David Waterson

Nicholas John Newcombe

Richard E Shute

David R Brittain

Robin Wood

Philip Cohen

Paul Robert Whittamore

Elaine Sophie Stokes

Elaine Sophie Elizabeth Stokes

John Graham Cumming

Murdoch A Eakin

William J Watkins

Paul Robert Owen

Alan John Foubister

The invention concerns amide derivatives of the Formula (I) wherein Ris (1-6C)alkyl or halogeno; Q is aryl or heteroaryl which optionally bears 1, 2, 3 or 4 substituents such as hydroxy, halogeno, trifluoromethyl, cyano, (1-6C)alkyl, (1-6C)alkoxy, halogeno-(1-6C)alkyl, hydroxyl-(1-6C)alkyl, di-[(1-6C)akly]amino-(1-6C)alkyl, hydroxy-(2-6C)alkoxy, (1-6C)alkoxy-(2-6C)alkoxy, di-[(1-6C)alkyl]amino-(2-6C)alkoxy, amino(2-6C)alkylamino, N-(1-6C)alkyl-(1-6C)alkylamino-(2-6C)alkylamino, aryl, aryl-(1-6C)alkoxy, heteroaryl, heteroaryl-(1-6C)alkoxy, heterocyclyl, heterocyclyl-(1-6C)alkyl, heterocyclyloxy and heterocyclyl-(1-6C)alkoxy; p is 0-2 and Ris a substituent such as hydroxy and halogeno; q is 0-4; and Rincludes optionally substituted aryl, cycloalkyl, heteroaryl and heterocyclyl; or pharmaceutically-acceptable salts or in-vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines. 

Amidobenzamide derivatives which are useful as cytokine inhibitors

The invention concerns amide derivatives of formula (I):wherein Ris (1-6C)alkyl or halogeno; Qis heteroaryl which is optionally substituted with 1, 2, 3, or 4 substituents such as hydroxy, halogeno, trifluoromethyl, (1-6C)alkyl, (1-6C)alkoxy, hydroxy-(1-6C)alkyl, (1-6C)alkoxy-(1-6C)alkyl, hydroxy-(2-6C)alkoxy, amino-(2-6C)alkylamino, N-(1-6C)alkyl-(1-6C)alkylamino-(2-6C)alkylamino, aryl, heteroaryl and heterocyclyl; p is 0-2 and Ris a substituent such as hydroxy and halogeno; q is 0-4; and Qincludes optionally substituted aryl, cycloalkyl, heteroaryl and heterocyclyl; or pharmaceutically-acceptable salts or in vivo-cleavable esters thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.

Amide derivatives useful as inhibitors of the production of cytokines

The invention concerns amide derivatives of Formula (I), wherein Ris (1-6C)alkyl or halogeno; m is 1-3 and Ris selected from substituents such as: (A) hydroxy, halogeno, (1-6C)alkyl, (1-6C)alkoxy, aryl, heteroaryl and heterocyclyl; and (B) di-[(1-6C)alkyl]amino-(1-6C)alkyl, (1-6C)alkoxy-(2-6C)alkoxy, di-[(1-6C)alkyl]amino-(2-6C)alkoxy, aryloxy, heteroaryloxy, heteroaryl-(1-6C)alkoxy, heterocyclyloxy and heterocyclyl-(1-6C)alkoxy; p is 0-2 and Ris a substituent such as hydroxy and halogeno; q is 0-4; and Ris aryl or cycloalkyl which bears 1-3 substituents such as: (C) hydrogen, hydroxy, halogeno and heterocyclyl; and (D) heteroaryl-(1-6C)alkoxy and heterocyclyl-(1-6C)alkoxy, provided that a substituent on Ris selected from paragraph (C) only if at least one Rgroup is selected from paragraph (B); processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.

Benzamide derivatives for the treatment of diseases mediated by cytokines

The invention concerns the use of amide derivatives of formula (I) wherein: R and R are substituents such as hydroxy, C alkoxy, mercapto, C alkylthio, amino, C alkylamino and di-(C alkyl)amino; m and p are independently 0-3; R is C alkyl; q is 0-4; and R is aryl or cycloalkyl; or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for use in the treatment of diseases or medical conditions mediated by cytokines

Amide derivatives for the treatment of diseases mediated by cytokines

The invention concerns the use of amide derivatives of formula (I) wherein: R and R are substituents such as hydroxy, C alkoxy, mercapto, C alkylthio, amino, C alkylamino and di-(C alkyl)amino; m and p are independently 0-3; R is C alkyl; q is 0-4; and R is aryl or cycloalkyl; or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for use in the treatment of diseases or medical conditions mediated by cytokines.

Bezamide derivatives for the treatment of diseases mediated by cytokines

The invention concerns the use of amide derivatives of formula (I) wherein: R and R are substituents such as hydroxy, C alkoxy, mercapto, C alkylthio, amino, C alkylamino and di-(C alkyl)amino; m and p are independently 0-3R is C alkyl; q is 0-4; and R is aryl or cycloalkyl; or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for use in the treatment of diseases or medical conditions mediated by cytokines

The invention concerns amide derivatives of Formula (I) wherein: R and R include hydroxy, C alkoxy, mercapto, C akylthio, amino and heterocyclyl; m and p are independently 0-3; R is halo, cyano or C alkoxy; q is 0-4; and R is aryl or cycloalkyl wherein R is optionally substituted with up to 3 substituents having any value defined for each R group; or a pharmaceutically-acceptable salt or in-vivo-cleavable ester thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by cytokines.

Benzamide derivatives and their use as cytokine inhibitors

Heterocyclic compounds useful as oxido-squalene cyclase inhibitors

This invention concerns heterocyclic derivatives of formula (I) which are useful in inhibiting oxido-squalene cyclase, processes for their preparation and pharmaceutical compositions containing them. The present invention is also concerned with heterocyclic derivatives capable of inhibiting cholesterol biosynthesis and hence in lowering cholesterol levels in blood plasma. The present invention also relates to methods of using such heterocyclic derivatives in diseases and medical conditions such as hypercholesterolemia and atherosclerosis.

Heterocyclic compounds useful as pharmaceutical agents

Substituted pyrimidine derivatives and their pharmaceutical use

Use of oxido-squalene cyclase inhibitors to lower blood cholesterol

Growing community of inventors

Wilmslow, United Kingdom

George R Brown