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United States of America As Represented by the Administrator of Nasa

George Nehmetallah

Thanh Van Nguyen

Shahid Aslam

Vy Bui

Thuc Phan

Imaging devices, methods, and systems are disclosed. The disclosure includes a Fourier Ptychographic Microscope ('FPM') compatible for integration to a Microfluidic Device (“MD”) to perform wide Field-of-View (“FoV”), high spatial resolution imaging (<1 μm), for biosignature detection and motility in liquid samples, for use, without limitation, as a space-based payload. Fourier ptychography (“FP”) algorithms adapted for reconstruction are disclosed. A processor board and camera combined with FP algorithms adapted for reconstruction are used to computationally reconstruct sub-micron resolution images. In certain embodiments, a dual-modality portable FPM performs wide FoV, high lateral and axial resolution imaging, and high-resolution birefringence imaging, for biosignature detection and motility in liquid samples. Various combinations of the disclosed devices, methods, and systems may be employed, depending on the particular requirements of each implementation.

Fourier ptychographic microscope systems and methods

A digital holography microscope, a method, and a system are provided. The digital holography microscope comprising two microscope objectives configured in a bi-telecentric configuration; a sample holder configured to receive a sample; a couple charged device configured to capture one or more images; a display; and a processor configured to retrieve a Convolutional Neural Network (CNN) model associated with a type of the sample, mitigate aberrations in the one or more images using at least the CNN model having as input an unwrapped phase associated with each of the one or more images, and output the mitigated one or more images via the display.

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Washington, DC, United States of America

George Nehmetallah