University of California

Rutgers, The State University of New Jersey

George Lommel Kenyon

Raymond F Schinazi

Fred Wudl

Craig L Hill

Fred Ehrenkranz Cohen

James H McKerrow

Zhe Li

Simon H Friedman

Rintje Pieter Sijbesma

Diane L DeCamp

Irwin D Kuntz

Philip Jon Rosenthal

Christine Sun Ring

Xiaowu Chen

Rongshi Li

Baoqing Gong

Edward Arnold

Diana C Roe

Malin Young

Andrew Leavitt

Angelika Muscate

Dolan Eargle

Karl Maurer

Margaret Stauber

Todd J Ewing

Allan G Skillman, Jr

Diane L De Camp

Vibhakar J Shah

A water soluble derivative of buckministerfullerene (C) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containing 1 to 20 carbon atoms and optionally further containing oxygen or nitrogen.

Method of treatment of viral infection including HIV using water soluble fullerenes&#x2014;III

A water soluble derivative of buckministerfullerene (C ) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containing 1 to 20 carbon atoms and optionally further containing oxygen or nitrogen.

Method of treatment of viral infection including HIV using water soluble fullerenes

Inhibitors of metazoan parasite proteases

A water soluble derivative of buckministerfullerene (C,) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containing 1 to 20 carbon atoms and optionally further containing oxygen or nitrogen.

Water soluble fullerenes with antiviral activity

The present invention relates to a novel class of compounds that are potent inhibitors of HIV reverse transcriptase and HIV integrase. In addition to being multienzyme inhibitors, the inventive compounds of the present invention are remarkable in at least two other respects. First, they do not appear to be toxic to cells at typical therapeutic concentrations. Second, they appear to be equally effective against mutant strains of HIV reverse transcriptase commonly found in patients who have developed resistance to current reverse transcriptase inhibitors. Because the inventive compounds show promise in combatting viral resistance and are potent inhibitors of both HIV reverse transcriptase and integrase, they are ideal candidates for use in combination with existing therapies or alone in treating AIDS or HIV infection.

Naphthols useful in antiviral methods

A water soluble derivative of buckministerfullerene (C.sub.60) having antiviral and virucidal properties is used to inhibit human retroviral replication and infections. The derivatized fullerene is symmetrically substituted with polar organic moieties containing 1 to 20 carbon atoms and optionally further containing oxygen or nitrogen.

Compositions and methods are disclosed for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease, wherein there is employed at least one compound of formula I

The present invention provides novel nucleic acid mimics (termed 'PENAMs') comprising a peptidic backbone and nucleotidic sidechains; the sidechains being oriented in such a way that the PENAM is homomorphous to target nucleic acids with which it can effectively hydrogen bond. Homomorphism is achieved by the incorporation of unusual sterochemical centers, including D-chiral centers and quasi-chiral centers, into the peptidic backbone. The PENAMs are useful for targeting nucleic acid sequences in order to modulate their activity in an 'antisense' manner. Targeting can also be used to detect, isolate or modify target nucleic acids.

Peptide-based nucleic acid mimics(PENAMS)

Growing community of inventors

San Francisco, CA, United States of America

George Lommel Kenyon