The Johns Hopkins University

Boston Scientific Scimed, Inc.

George L Coles

Howard W Francis

Dawnielle Farrar-Gaines

Jason J Benkoski

Chao-Wei Hwang

Morgana M Trexler

David A Kitchin

Hala J Tomey

Robert C Matteson, Iii

Ioan Lina

Jon R Resar

Pankaj Jay Pasricha

Ryan V Wales

John Thomas Favreau

Richard S Potember

Umang Anand

Sritam Parashar Rout

Honggang Cui

Dennis Werner

Philippe Martin Burlina

Youseph Yazdi

Wayne I Sternberger

Xiomara Calderon-Colon

Gordon Tomaselli

Stephen J Meltzer

Amir Hossein Soltanianzadeh

Florin M Selaru

Robert G Weiss

Dawnielle Farrar

Marc Chelala

Maria F Torres

Gary Gerstenblith

Peter V Johnston

Timothy P Harrigan

Kyle R Cowdrick

David M Gullotti

Kalyna Sconzert

Jeffrey A Brinker

James Cawthra

Steven P Schulman

Reggie Roth

Jason Kilvington

James Duncan Beaty

John H Benson

Demetri Monovoukas

Keith Bulkin

Sybil Klaus

Joseph A Walters

Eric Jackson

Benjamin Elder

Ramji Rengarajan

Kenton J Zehr

Victor San Hou Yu

Todd Christopher Crawford

Jon R Rosar

Tom Jancaric

The present disclosure relates generally to the field of medical devices and establishing access to body passageways. In particular, the present disclosure relates to devices, systems and methods to facilitate entry of an endoscopic accessory tool into and/or through patient-specific anatomies. For example, the devices, systems and methods of the present disclosure may transmit mechanical motion to the distal end of an endoscopic accessory tool to facilitate atraumatic access to tortuous or otherwise restricted anatomies.

Devices, systems and methods for transmitting motion to the distal tip of an endoscopic accessory tool

A buoy system for treating cardiac valve regurgitation comprising a movable plug having atrial and ventricular ends, wherein a through-hole passes from the atrial to the ventricular end, wherein during systole, the plug travels toward a cardiac atrium, wherein during diastole, the plug travels into a cardiac ventricle; a tether having atrial and ventricular ends, wherein the tether passes through the through-hole of the moving plug, wherein the atrial end of the tether projects into an atrium, wherein the atrial end of the tether includes a cap to engage a delivery tool; at least one distal anchor located in the ventricle, wherein the distal anchor is coupled to the ventricular end of the tether, and wherein the system is percutaneously delivered and optionally recaptured via catheter and recapture tool at the cap of the tether, respectively.

Systems and methods of treating malfunctioning cardiac valves

Described are devices for treating disease in subjects wherein the devices include a sponge comprising a hydrogel, extracellular vesicles (EVs), and an agent. Methods of using the devices to treat or prevent disease such as esophageal adenocarcinoma are also described.

Device and method to treat esophageal disorders

Example substances and methods relating to contrast agents are provided. An example method includes combining a surface active protein, a stabilizer, and a dispersion media to form a solution. The example method may further include aerating the solution in a gas to form a contrast agent comprising at least one microbubble formed from an interaction between the surface active protein and the stabilizer. A diameter of the at least one microbubble may be proportional to a pressure of an external environment of the contrast agent, such that measurement of the diameter may allow for measurement of the pressure.

Contrast agent and associated methods

A middle ear implant may include a first interface portion configured to interface with a first structure of a middle ear of a patient, a second interface portion configured to interface with a second structure of the middle ear of the patient, a shaft configured to connect the first interface portion and the second interface portion, and a sensor disposed at one end of the shaft, between the shaft and one of the first interface portion or the second interface portion. The sensor may be configured to provide a DC signal output indicative of static pressure on the sensor based on placement of the sensor between the first and second structures. The sensor may also be configured to provide an AC signal output indicative of a frequency response of the implant in response to the sensor being coupled to an output device.

Middle ear implant sensor

A method for promoting healing of tissue by delivering a bioreactor into a subject is provided. The bioreactor is an enclosed housing with paracrine factor producing cells enclosed within the housing. The housing is impermeable to the paracrine factor producing cells, impermeable to immunological cells outside of the housing, and permeable to paracrine factors produced by the paracrine factor producing cells. The paracrine factors produced by the paracrine factor producing cells are released out of the housing to promote healing of the tissue.

Methods for promoting healing of tissue

A middle ear implant includes a first interface portion configured to interface with a first structure of a middle ear of a patient, a second interface portion configured to interface with a second structure of the middle ear of the patient, a shaft that connects the first and second interface portions, a carrier plate removably mounted in one of the first or second interface portions, and a removable sensor disposed at one end of the shaft, between the shaft and one of the first interface portion or the second interface portion. The removable sensor is configured to provide a DC signal output indicative of static pressure on the sensor based on placement of the sensor between the first and second structures, and provide an AC signal output indicative of a frequency response of the implant. The removable sensor is disposed at a portion of the carrier plate.

Removable middle ear implant sensor

Implantable pressure-actuated systems to deliver a drug and/or other substance in response to a pressure difference between a system cavity and an exterior environment, and methods of fabrication and use. A pressure-rupturable membrane diaphragm may be tuned to rupture at a desired rupture threshold, rupture site, with a desired rupture pattern, and/or within a desired rupture time. Tuning may include material selection, thickness control, surface patterning, substrate support patterning. The cavity may be pressurized above or evacuated below the rupture threshold, and a diaphragm-protective layer may be provided to prevent premature rupture in an ambient environment and to dissipate within an implant environment. A drug delivery system may be implemented within a stent to release a substance upon a decrease in blood pressure. The cavity may include a thrombolytic drug to or other substance to treat a blood clot.

Method of manufacturing an implantable pressure-actuated drug delivery system

A ventriculoperitoneal shunt includes a proximal catheter, a distal catheter, a shunt valve operably coupling the proximal catheter to the distal catheter, and a contrast container containing contrast material configured to change acoustic impedance proportionally to a change in pressure applied to the contrast container.

Ventriculoperitoneal shunt with pressure responsive element

Methods of manufacture and use of implantable pressure-actuated drug delivery systems

Implantable pressure-actuated drug delivery systems and methods of manufacture and use

Growing community of inventors

Baltimore, MD, United States of America

George L Coles