Union Carbide Corporation

Union Carbide Chemicals and Plastics Company, Inc.

Union Carbide Industrial Gases Technology Corporation

Integra Lifesciences Corporation

Other

Amoco Corporation

Rutgers, the State University of New Jersey

Union Carbide Chemicals & Plastics Technology Corporation

Biomatrix, Inc.

The Medical College of Hampton Roads

Biomaterials Corporation

George L Brode

You-Ling Fan

Sui-Wu Chow

Emmett Malone Partain, Iii

Hugh C Gardner

Errol D Goddard

James H Kawakami

Robert J Cotter

Meyer R Rosen

Michael J Michno, Jr

Frederick Maynard Merritt, Ii

James P Stanley

George A Salensky

Joachim B Kohn

Pak S Leung

Adolf Leshchiner

Russell Lowell Kreeger

Joseph P Pavlichko

Philip A Band

Natarajan Muruganandam

Arminda G Barbone

John E Kemnitzer, Iii

Warren F Hale

Durgadas Bolikal

Nan S Chu

Gustavo F Doncel

David B Braun

Russell L Kreeger

Timothy Irvin Malaney

John Kemnitzer

Shuiyun Guan

Sylvie I Ertel

Henry L Gabelnick

Robert Minasyan

A process for selectively modifying pendent functionalities of a polymer containing the pendent functionalities and hydrolytically unstable backbone functionalities is provided. The process includes: (a) providing the polymer in a solvent system (preferably an ether-containing solvent system) adapted to maintain the polymer in a dissolved or partially dissolved state, wherein the pendent functionalities of the polymer are more accessible than the hydrolytically unstable backbone functionalities; and (b) adding at least one additive to the solvent system to selectively modify at least one of the pendent functionalities. The process is especially well suited for specifically acid hydrolyzing pendent esters of PDTE.

Selective modification of pendent functionalities of polymers

Improvements are disclosed for biphasic polymerization processes in which an aqueous solution of a first monomer that is hydrolytically unstable below a pH of about six or above a pH of about eight is admixed with a water-immiscible organic solvent and there is added to the admixture a catalyst selected from tertiary amine, quaternary amine and phosphonium catalysts, an acid-forming co-monomer for the first monomer, an acid scavenger, after which the resulting polymer is recovered, wherein the improvement includes providing the aqueous solution at a pH between about si and about eight, and adding to the admixture the acid-forming co-monomer and the acid scavenger at relative rates effective to maintain the pH of the admixture between about six and about eight. The catalyst may be added in a molar ratio to the first monomer effective to provide a predetermined weight-average or number-average molecular weight for the resulting polymer. Biphasic polymerization processes for monomers that are not pH sensitive are also disclosed.

Biphasic polymerization process

A polymer with a hydrolytically labile backbone and having the structure: ##STR1## wherein R.sub.9 is an alkyl, aryl or alkylaryl group with up to 18 carbon atoms having a pendent carboxylic acid group or the benzyl ester thereof; R.sub.12 is an alkyl, aryl or alkylaryl group with up to 18 carbon atoms having a pendent carboxylic acid ester group selected from straight and branched alkyl and alkylaryl esters containing up to 18 carbon atoms and ester derivatives of biologically and pharmaceutically active compounds covalently bonded thereto, provided that the ester group is not a benzyl group or a group that is removed by hydrogenolysis; each R.sub.7 is independently an alkylene group containing up to four carbon atoms; A is selected from: ##STR2## wherein R.sub.8 is selected from saturated and unsaturated, substituted and unsubstituted alkyl, aryl and alkylaryl groups containing up to 18 carbon atoms; k is between about 5 and about 3,000; and x and f independently range from zero to less that one.

Biodegradable, anionic polymers derived from the amino acid L-tyrosine

Improved contraceptive compositions are disclosed which comprise a spermicide or virucide, a polymeric delivery component and optionally a cosmetic ingredient. The improvement is directed to the use of certain hydrophobically modified polysaccharides as the polymeric delivery component. Quite advantageously, the hydrophobically modified polysaccharides of the present invention can alter sperm motility. Moreover, the hydrophobically modified polysaccharides can provide reduced irritation potential when used in combination with spermicides such as, for example, nonoxynol-9, which may reduce the potential for infection of sexually transmitted diseases such as HIV and herpes.

Contraceptive compositions

Double-substituted, water-soluble, cellulose ethers substituted with a cationic substituent and a hydrophobic substituent are disclosed. The levels of substitution for the cationic substituent and the hydrophobic substituent can provide enhanced properties when used in personal care compositions, such as, for example, enhanced substantivity, saline capability and low irritation potential to mucosal linings.

Double-substituted cationic cellulose ethers

The invention relates to a method for topical application of a pharmaceutically or therapeutically active agent through the use of a covalent chitosan derivative or chitosonium polymer. The present invention is particularly well suited for the topical delivery of pharmaceutically active quaternary ammonia compounds of the formula: ##STR1## wherein R is alkyl having between 5 and 11 carbon atoms.

Delivery systems for quaternary and related compounds

Permeable membranes comprised predominantly of specifically defined tetrabromobisphenols and aromatic dicarboxylic acids. The invention also pertains to the novel permeation processes for recovery of an oxygen/nitrogen or carbon dioxide/methane component form a mixture of said component with other components.

Semipermeable membranes based on specified tetrabromobisphenol type

A biocompatible, film-forming delivery system for the delivery of pharmaceutical or therapeutic actives to a desired topical site of a subject, the system including:

Polymeric salt delivery systems

Permeable membranes comprised predominantly of specifically defined polyester of 4,4'-(1H-alkylidene)bis[2,3,6-trialkylphenol] and aromatic dicarboxylic acids. The invention also pertains to the novel permeation processes for recovery of an oxygen/nitrogen or carbon dioxide/methane or helium/methane component from a mixture of said component with other components in the mixture.

Semipermeable membranes based on specific

Cationic, anionic and amphoteric polymers suitable for the preparation of acid viscosifier compositions and the acid viscosified compositions are provided. The polymers are water soluble or water dispersible and are based on acrylyl monomers having the stated ionic charge. They are capable of viscosifying acid solutions that have important use in recovery of gas and oil from subterranean formations.

Acid viscosifier compositions

Delivery systems containing at least one aminopolysaccharide derivative are provided for the delivery of pharmaceutical or therapeutic actives to a desired topical or mucous membrane site in a subject, and wherein upon delivery, the systems provides a biocompatible, substantive, gas permeable, film from which actives are available at the designated site.

Delivery systems for pharmaceutical or therapeutic actives

Combinations of glycosaminoglycan and certain cationic polymers provide modified glycosaminoglycan properties and can provide substantivity to keratinous material, compatibility, stability, humectancy, rheology and other properties useful in personal care or medical applications.

Processes for managing keratinous material using glycosaminoglycan and

Gelable acid compositions containing novel crosslinkable copolymers and the novel copolymers. The copolymers contain an N-(alkoxymethylene)acrylyl moiety. In addition there are provided gelable acid compositions containing a group of polyfunctional reactants that contain a plurality of --CH.sub.2 OH and/or --CH.sub.2 CH.sub.2 OH groups in the molecule.

Gelable acid viscosifiers

Partially hydrolyzed, poly(N-acyl alkylenimines), and novel nitrogen-substituted derivatives thereof, provide useful and improved personal care compositions and processes.

Partially hydrolyzed, poly(N-acyl alkylenimines) in personal care

Partially hydrolyzed, poly(N-acyl)alkylenimines), and novel nitrogen-substituted derivatives thereof, provide useful and improved personal care compositions and processes.

Partially hydrolyzed, poly(N-acyl)alkylenimines in personal care

Growing community of inventors

Bridgewater, NJ, United States of America

George L Brode