Integra Biosciences Corp.

Integra Biosciences Ag

Viaflo Corporation

George Kalmakis

Gary Nelson

Gregory Mathus

Richard Cote

Terrence Kelly

David Earl Butz

Joel Novak

Kenneth Steiner

Jonathan Harkins

David Edward Roche

Jonathon Finger

Laurence Keene

Stanley O Thompson

R Laurence Keene

Christopher Labak

Jonathan Finger

Alex Therrien

Pipetting containers, such as reservoirs, reservoir liners, microplates, PCR plates, microtubes and PCR tubes, include anti-vacuum channels on the bottom wall of the receptacle to prevent a pipette tip vacuum engaging the wall during aspiration. The groupings of anti-vacuum channels are located on the bottom surface facing upward into the basin that holds liquid samples or reagents. The anti-vacuum channels also lower the required working volume for pipetting and reduce liquid waste.

Sample and reagent containers with anti-vacuum feature

A pipetting reservoir kit includes a base, a disposable liner, and a lid. The disposable liner includes anti-vacuum channels on the bottom wall to prevent a pipette tip vacuum engaging the wall during aspiration. The groupings of anti-vacuum channels located on the bottom surface of the liner face upward into the basin that holds liquid samples or reagents. The groupings of anti-vacuum channels are spaced in an array 4.5 mm apart for a 384 pipetting head and 9 mm apart for a 96 pipetting head. The anti-vacuum channels also lower the required working volume for the liner and reduce liquid waste.

Sample and reagent reservoir kits and liners with anti-vacuum feature

A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.

Multi-channel pipettor with repositionable tips

Multi-channel pipettor with variably repositionable tips

Programmable multi-channel pipettor with repositionable tips

A hand-held electronic pipettor is designed particularly to be programmed and operated with one hand for the convenience of the user. It uses a capacitance touchpad control for programming, and a separate run button for the operating mode. Internal components are located so that the center of gravity of the pipettor is located within the palm of the user. Flash memory stores an empirically derived table that correlates aspiration volume to motor steps and a separate empirically derived table the correlates dispensing volumes to motor steps.

Electronic pipettor with improved accuracy

A hand-held electronic pipettor includes menu driven software for controlling the information displayed on the user interface display, for inputting information to program the pipettor and for controlling the operation of the pipettor.

Pipettor software interface

Multi-channel pipette

Pipette

Electronic pipettor

Growing community of inventors

Gloucester, MA, United States of America

George Kalmakis