Beckman Instruments, Inc.

George K Shibata

Wing S Pang

Dobson M Okawa

Peter Kan

Dang Minh Ngo

Wings S Pang

A system for analyzing a chemical reaction provides control of the temperature and volume of the reagents to improve the accuracy and precision in quantitative measurements of specific proteins and other immunochemistries in body fluids. The reaction occurs in a cuvette within a nephelometric optics module. A sensor senses the temperatures of reaction buffer liquids as they flow into the cuvette, and a heat exchanging device increases or decreases the temperatures of the buffer liquids. A control circuit responsive to the temperature sensor controls the heat exchanging device to maintain the temperature of the buffer liquids and the cuvette within a selected temperature range. The system may also include a sample pickup station, a sample probe for withdrawing a selected sample from the sample pickup station, a sample preparation station, and transport device for carrying said sample from the sample preparation station to the reaction cuvette. The system may include an antibody pickup station, an antibody probe for withdrawing an antibody from the antibody pickup station, an antibody preparation station, and antibody transport device for carrying the antibody from the antibody preparation station to the reaction cuvette.

Automatic immunochemistry analyzing apparatus and method

A system for analyzing a chemical reaction provides control of the temperature and volume of the reagents to improve the accuracy and precision in quantitative measurements of specific proteins and other immunochemistries in body fluids. The reaction occurs in a cuvette within a nephelometric optics module. A sensor senses the temperatures of reaction buffer liquids as they flow into the cuvette, and a heat exchanging device increases or decreases the temperatures of the buffer liquids. A control circuit responsive to the temperature sensor controls the heat exchanging device to maintain the temperature of the buffer liquids and the cuvette within a selected temperature range. The system may also include a sample pickup station, a sample probe for withdrawing a selected sample from the sample pickup station, a sample preparation station, and a sample transport for carrying said sample from the sample preparation station to the reaction cuvette. The system may include an antibody pickup station, an antibody probe for withdrawing an antibody from the antibody pickup station, an antibody preparation station, and an antibody transport for carrying the antibody from the antibody preparation station to the reaction cuvette.

Method of performing nephelometric analysis with independent temperature

Apparatus for controlling reaction temperatures in a chemical analyzer comprises a thermoelectric element operating in response to a temperature sensor, and control means capable of predicting a setpoint deviation for a future time period, and, when an overshoot is predicted, reducing a control signal for the element by an amount proportional to a current setpoint deviation. The apparatus includes at least one reaction cell and a buffer unit for thermally stabilizing a fluid that is fed, on demand, into the reaction cell, the cell and the buffer unit having separate thermoelectric elements and sensors. A microcomputer control system generates independent control signals for the elements.

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Chino, CA, United States of America

George K Shibata