G.d. Searle & Company

George J Ellames

Albert A Jaxa-Chamiec

Roger M Upton

Paul W Manley

Kevin Robert Lawson

Peter J Fellner

Peter L Myers

Christopher D Floyd

This disclosure relates to a compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 and R.sup.2 are independently selected from the class consisting of hydrogen, halo, C.sub.1 -C.sub.6 alkyl, and C.sub.1 -C.sub.6 alkoxy;

Substituted 1H-pyrimido[1,2-a-]-pyrido[3,4-e]pyrazine 6 oxides

This disclosure relates to a novel class of substituted quinoxaline derivatives. The disclosure further relates to pharmaceutical compositions containing such compounds and to the use of such compounds and compositions as anti-anaerobic agents.

Substituted pyrimidoquinoxalines useful as anti-anaerobic agents

This disclosure relates to a novel class of substituted dihydroimidazo[1,2-a]quinoxaline derivatives. The disclosure further relates to pharmaceutical compositions containing such compounds and to the use of such compounds and compositions as anti-anaerobic agents.

Substituted dihydroimidazo[1,2-a]quinoxalines

Compounds of the general formulae: ##STR1## in which Ar and Ar.sup.1 which may be the same or different represent aromatic radicals optionally substituted once or more than by substituents selected from halogen, lower alkyl and lower alkoxy and Alk represents an alkylene group containing from 1 to 4 carbon atoms which alkylene group may be interrupted with a heteroatom; and acid addition salts thereof. These compounds have anti-anaerobe and also anti-fungal activity and are non-mutagenic.

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High Wycombe, United Kingdom

George J Ellames