Ortho Pharmaceutical Corporation

Immunobiology Research Institute, Inc.

George Heavner

Gideon Goldstein

Tapan Audhya

Daniel J Kroon

Foe-Siong Tjoeng

Mohmed K Anwer

Tetrapeptides and pentapeptides are disclosed which are capable of regulating the function of cells of the mammalian immune system. Also provided are pharmaceutical compositions containing the peptides and methods of use thereof.

Tetra and penta-peptides useful in regulating the immune system

Pentapeptides are disclosed which are capable of regulating the function of cells of the mammalian immune and/or nervous system. Also provided are pharmaceutical compositions containing the peptides and methods of use thereof.

Peptides useful in regulating the immune and nervous systems

A multi-functional mammalian peptide probursin isolated in purified form, produced synthetically or recombinantly can be used therapeutically for treatment of immune disorders and tumor inhibition.

Probursin

Synthetic peptides which possess the ability to specifically induce the differentiation of precursor B cells into mature B-cells capable of producing antibody.

B cell differentiating peptides and conjugates thereof

B-cell differentiating peptides

Immunoregulating peptides are disclosed which are more potent than thymopentin or splenin and are useful for their effects on the immune system, especially the treatment of thymic deficiencies.

Potent thymopentin analogs

A synthetic peptide which possesses the ability to specifically induce the differentiation of precursor B cells into mature B-cells capable of producing antibody.

Bursopoietin

Immunoregulating peptides are disclosed which are cyclic peptides similar to thymopentin. These peptides are useful for their effects on the immune system, especially the treatment of thymic deficiencies.

Conformationally restricted thymopentin-like compounds

Peptides which have thymopoeitin-like or splenin-like activity combined with greatly increased resistance to degradation by enzymes. The peptides are useful for treatment of immunoregulatory disorders. Also provided are methods of treating immunoregulatory disorders and compositions used in these methods.

Enzyme-resistant immunomodulatory peptides

There are disclosed peptides having the following formula:

Peptides having thymopoietin-like activity

The present invention relates to methods for preparing useful peptides, more particularly to solution synthesis methods for preparing H-ARG-X-Z-Y-TYR-R, intermediates in the preparation of this peptide and to compositions of this peptide useful in thymic function.

N-Protected pentapeptides useful as intermediates in the preparation of

Immunoregulatory 2,5-diketopiperazine compounds of formula: ##STR1## wherein m is 1 or 2 and n is 3 or 4 possess the ability to regulate the immune system of humans and animals. Administration of the compounds will return to a normal state an immune system in need of regulation.

Immunoregulatory diketopiperazine compounds

Solution phase methods and compositions for preparing H-ARG-X-Z-Y-TYR-R wherein X is LYS and Y is VAL or X and Y are both SAR, Z is ASP or GLU, and R is NH.sub.2 or OH.

Methods and compositions for preparation of H-ARG-X-Z-Y-TYR-R

There are disclosed peptides having the following formula: 1

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Flemington, NJ, United States of America

George Heavner