William H. Rorer, Inc.

Other

Rorer Pharmaceutical Corporation

George H Douglas

William L Studt

Julius Diamond

Stuart A Dodson

Norman J Santora

Chong M Won

Henry F Campbell

John Yelnosky

George W Nuss, Jr

Richard L Riley

Jerome J Zalipsky

Ghulam N Mir

Harry K Zimmerman

Dahyabhai M Patel

Bernard J Burns

George A Condouris

Thomas H Scholz

Ronald L Alioto

Paul R Darkes

June Douglas

Norman F Santora

A protective roller screen assembly for helping prevent projectiles moving at a high velocity from passing through a window or doorway. The protective roller screen assembly includes a frame that has a pair of upright members, an upper cross member that extends between upper ends of the upright members, and a lower cross member that extends between lower ends of the upright members. Each of the upright members has inner and outer sides, front and back sides, and an interior that is defined between the sides. Each of the inner sides of the upright members has a guide slot extending therethrough between the upper and lower ends of the upright members. A screen extends downwardly from the upper cross member. Opposed side ends of the screen are slidably disposed in the guide slots of the upright members. The screen is positionable between an extended position and a retracted position. The bottom end of the screen is positioned towards the lower cross member when the screen is positioned in the extended position. The bottom end of the screen is positioned towards the upper cross member when the screen is positioned in the retracted position.

Protective roller screen assembly

This invention relates to a method of lowering blood pressure in humans and mammals using 2,6-disubstituted phenyl amidinoureas in which the phenyl ring is additionally substituted by a hydroxy, alkoxy, aralkoxy, alkenyloxy, alkynyloxy, haloacyloxy, or acyloxy group and to novel 2,6-disubstituted phenyl amidinoureas which possess pharmaceutical properties, including blood pressure lowering activity.

Substituted phenyl amidinoureas

This invention relates to a novel class of heterocyclic amidinourea and heterocyclic amidinothiourea compounds wherein the heterocyclic substitution is at the 1-N urea nitrogen atom. These compounds exhibit pharmaceutical activity and may be incorporated into pharmaceutical preparations for producing anti-ulcerogenic, antisecretory, antispasmodic, antimotility, cardiovascular, antidiarrheal or antiparasitic action.

Heterocyclic amidinoureas

A method of inducing blood pressure reduction in humans and mammals by administering 2,6-disubstituted phenyl N-alkyl amidinoureas in which the phenyl ring is additionally substituted by a hydroxy, alkoxy, aralkoxy, alkenyloxy, alkynyloxy, acyloxy or halo acyloxy group and a novel class of amidinourea compounds having pharmaceutical uses, including blood pressure lowering activity.

Amidinoureas substituted in both the urea and amidino nitrogen positions

A novel method of treating gastrointestinal, spasmolytic and ulcerogenic disorders by the administration of amidinoureas is disclosed.

Amidinoureas

Novel phenylamidinourea compounds and processes for their preparation are described. These compounds have an effective degree of anti-hypertensive properties and exert activities on the cardiovascular system. A method for the treatment of hypertensive disorders is also described.

##STR1## This invention relates to 1-aryl-4-hydrazinyl-1,2-dihydro-1,3,5-triazin-2-ones and 2-thiones of Formula I, processes for their preparation, isobiuret and 4-alkoxy-s-triazinone preparative intermediates, and methods of treating physiological disorders in humans and animals, in particular, cardiovascular disorders, including hypertension.

1-Aryl-4-hydrazinyl-s-triazin-2-ones

Novel s-triazine compounds are prepared as derivatives of the corresponding amidinourea and amidinothiourea compounds by reacting with an activated form of an acid amide to give substituted s-triazinones and thiones respectively, of the formula ##STR1## The s-triazinones and thiones are useful derivatives in analyzing for the corresponding amidinourea or amidino thiourea precursors and also have useful pharmacological properties which make them suitable for a variety of medicinal purposes including use as antidiarrheal agents.

Triazinones

This invention relates to a novel class of amidinourea and amidinothiourea compounds wherein the urea nitrogen atom is substituted by a heterocyclic alkylene group, and their use in pharmaceutical preparations which are useful for producing anti-ulcerogenic, antisecretory, antispasmodic, antihypertensive, anesthetic, anti-arrhythmic, antidiarrheal and antiparasitic action.

Pyridyl alkylene amidinoureas

A new class of chemical compounds and their process of preparation is described. These compounds have valuable properties as anti-secretory, anti-spasmodic, anti-ulcerogenic and anti-diarrheal agents.

This invention relates to a novel class of heterocyclic amidinourea and heterocylic amidinothiourea compounds wherein the heterocyclic substitution is at the 1-N urea nitrogen atom. These compounds exhibit pharmaceutical activity and may be incorporated into pharmaceutical preparations for producing anti-ulcerogenic, antisecretory, antispasmodic, antimotility, cardiovascular, antidiarrheal or antiparasitic action.

This invention describes a new class of 1-amidino-3-phenylthiourea and N'-phenylamidinothiourea compounds wherein the phenyl group is ortho substituted, and processes for their preparation. The phenylamidinothiourea compounds may be incorporated into pharmaceutical preparations which are useful for producing anti-ulcerogenic, antisecretory, antispasmodic, antihypertensive, anti-arrhythmic, anesthetic, antidiarrheal and antiparasitic action.

Amidinothioureas

##STR1## This invention relates to 6-aryl-4-hydrazinyl-1,2-dihydro-1,3,5-triazin-2-ones and 2-thiones of Formula I, processes for their preparation, intermediates useful in said processes and methods of treating physiological disorders in humans and animals, in particular, cardiovascular disorders, including hypertension.

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Malvern, PA, United States of America

George H Douglas