American Home Products Corporation

George Greenspan

Michael R Leeming

Richard W Rees

Peter B Russell

A method for the elaboration of large quantities of Bordetella pertussis protective antigens useful in the production of acellular vaccines for prevention of whooping cough.

Stimulation of antigen production by Bordetella pertussis

New, substituted, 2,6-diaminopyrimidines are disclosed. These compounds are useful as anti-malarial agents. The oxygenation of pyrimethamine by fungi is also disclosed.

Synthesis of 2,6-diaminopyrimidines

Reduction of 7(2-[(3R and 3S)-3-hydroxy-1-octenyl]-5-oxo-3-cyclopenten-1-yl)-5-heptenoic acid by microorganisms of the genera Streptomyces, Pseudomonas and Corynebacterium is disclosed. The products 7-(2-[(3R)-3-hydroxy-1-octenyl]-5-oxo-cyclopentyl)-5-heptenoic acid(11-deoxy-15-epi-PGE.sub.2), which is novel, and 7-(2-[(3S)-3-hydroxy-1-octenyl]-5-oxo-3-cyclopentyl)-5-heptenoic acid(11-deoxy-PGE.sub.2), respectively, are useful as intermediates for the synthesis of other physiologically active ingredients.

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Narberth, PA, United States of America

George Greenspan