Emd Millipore Corporation

Millipore Corporation

George Gagne

Kurt E Greenizen

John Doyle

Louis L Bonhomme

Sean Devin

Gerard Lombard

Vincent Smith

Wilson Moya

David DeCoste

John Saragosa

Benjamin Cacace

Mark Kavonian

Stefano Berti Perez

Shannon Cleveland

Marina Varlamova

Daniel Lamothe

James Dee

Louis Bonhomme

A biocontainer having a first film, the film having an interior and exterior side; articulating elements disposed on or within the first film, the articulating elements comprising at least one a folded hinge, a sealed joint, a thinned pathway, a bowed path, an embedded polymeric or metallic cylindrical fiber or rod; and a second film, optionally comprising articulating elements, joined to the first film, to form a biocontainer having a closed volume, wherein the articulating elements permit the biocontainer to expand and collapse along the articulating elements.

Articulating biocontainers

Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device. The two-panel configuration also maintains more available membrane area in use during the last stages of filtration than a one-panel configuration.

Centrifugal filter

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Dracut, MA, United States of America

George Gagne