International Business Machines Corporation

Intermec IP Corporation

Other

George Frederick Walker

Paul Alfred Lauro

Brian Samuel Beaman

Da-Yuan Shih

Sampath Purushothaman

Keith E Fogel

Maurice Heathcote Norcott

Kevin Shawn Petrarca

Richard Paul Volant

Carlos Juan Sambucetti

Sung Kwon Kang

John J Ritsko

Jane M Shaw

Alfred Viehbeck

Daniel C Edelstein

Kang-Wook Lee

Paul Andrew Moskowitz

Terrence Robert O'Toole

Eugene John O'Sullivan

Gustavo Alejandro Stolovitzky

Michael John Brady

John Harold Magerlein

Judith Marie Rubino

Kie Y Ahn

James L Hedrick

Peter Alfred Gruber

Fuad Elias Doany

Clifford A Pickover

James R Kozloski

Voya Rista Markovich

Timothy Joseph Dalton

Marie Angelopoulos

Wu-Song S Huang

Harley K Heinrich

Stephen Mark Rossnagel

Stefan Harrer

James W Murdock, Iv

Charles Hampton Perry

Glenn John Martyna

James Marc Leas

Hongbo Peng

Binquan Luan

Tien-Jen Cheng

Thomas Anthony Cofino

John Gerard Gaudiello

Glen Walden Johnson

Anthony P Ingraham

Maurice McGlashan-Powell

Sherif Ahmed Goma

Robert J Twieg

Christopher Vincent Jahnes

Young-Ho Kim

Thomas M Shaw

Chandrasekhar Narayan

Jerome J Cuomo

Emanuel Israel Cooper

Harold John Hovel

Stanislav Polonsky

Leathen Shi

David Noel Light

Raymond R Horton

David Lewis Gardell

Qiang Huang

Shaji Farooq

Douglas Oliver Powell

Sarah Huffsmith Knickerbocker

Chao Wang

Ajay K Royyuru

Xiaoyan Shao

Alphonso Philip Lanzetta

Robert Anthony Rita

Deqiang Wang

Rao Venkateswara Vallabhaneni

Horatio Seymour Wildman

Thomas P Gall

Peter Richard Duncombe

Ali Afzali-Ardakani

Michael A Gaynes

Paul Stephen Andry

Edmund Juris Sprogis

Gareth Geoffrey Hougham

Xiao Hu Liu

Jon Alfred Casey

Robert Allen Groves

Bruce Kenneth Furman

Cornelia K Tsang

Anilkumar Chinuprasad Bhatt

Arthur R Zingher

Steven Paul Ostrander

Maheswaran Surendra

Brian Richard Sundlof

Mark B Ritter

David Andrew Lewis

Michael Wayne Lane

Madhav Datta

Chirag Suryakant Patel

Judith Marie Roldan

Yu-Ting Cheng

Leena Paivikki Buchwalter

Michelle Leigh Steen

A mechanism is provided for reducing entropy of a polyelectrolyte before the polyelectrolyte moves through a nanopore. A free-standing membrane has the nanopore formed through the membrane. An agarose gel is formed onto either and/or both sides of the nanopore in the membrane. The agarose gel is a porous material. The polyelectrolyte is uncoiled by driving the polyelectrolyte through the porous material of the agarose gel via an electric field. Driving the polyelectrolyte, having been uncoiled and linearized by the agarose gel, into the nanopore is for sequencing.

Reduction of entropic barrier of polyelectrolyte molecules in a nanopore device with agarose gel

Exemplary methods and devices herein receive an inquiry and automatically analyze words used in the inquiry, potential answers, and data maintained by evidence sources using the computerized device to determine the sensitivity level associated with the inquiry. The sensitivity level associated with the inquiry represents an emotional and cognitive state of the user. Such methods and devices automatically generate at least one follow-up question based on the sensitivity level associated with the inquiry and receive a follow-up response into the computerized device in response to the follow-up question(s). The methods and devices also automatically produce scores for the potential answers using the computerized device based on the inquiry, the follow-up responses, and ratings of the evidence sources. Following this, these methods and devices automatically generate output answers to the inquiry based on the sensitivity level associated with the inquiry using the computerized device.

Empathy injection for question-answering systems

A system of controlled translocation of macromolecules by gel electrophoresis employs a funnel nanopore structure. A graphene portion is attached to a porous material layer including funnel-shaped pores such that the graphene portion blocks the side of the porous material layer having openings for smaller pores. A pair of electrical contacts is formed on the graphene portion. A dielectric material layer may be deposited to hold the graphene portion in place. A nanoscale hole is formed through the dielectric material layer and the graphene portion to provide a smallest opening in a funnel nanopore structure. The funnel nanopore structure is placed within a capsule configured for gel electrophoresis. A linear chain of molecules can pass through a funnel-shaped pore and the nanoscale hole during the gel electrophoresis. A graphene nanopore detector allows measurement of blockage current for sufficient resolution of base pairs in DNA's.

Controlled translocation of macromolecules employing a funnel nanopore structure and a gel

A system of controlled translocation of macromolecules by gel electrophesis employs a funnel nanopore structure. A graphene portion is attached to a porous material layer including funnel-shaped pores such that the graphene portion blocks the side of the porous material layer having openings for smaller pores. A pair of electrical contacts is formed on the graphene portion. A dielectric material layer may be deposited to hold the graphene portion in place. A nanoscale hole is formed through the dielectric material layer and the graphene portion to provide a smallest opening in a funnel nanopore structure. The funnel nanopore structure is placed within a capsule configured for gel electrophoresis. A linear chain of molecules can pass through a funnel-shaped pore and the nanoscale hole during the gel electrophoresis. A graphene nanopore detector allows measurement of blockage current for sufficient resolution of base pairs in DNA's.

Segmented semiconductor nanowires are manufactured by removal of material from a layered structure of two or more semiconductor materials in the absence of a template. The removal takes place at some locations on the surface of the layered structure and continues preferentially along the direction of a crystallographic axis, such that nanowires with a segmented structure remain at locations where little or no removal occurs. The interface between different segments can be perpendicular to or at angle with the longitudinal direction of the nanowire.

Super lattice/quantum well nanowires

A technique for nanodevice is provided. A reservoir is filled with an ionic fluid. A membrane separates the reservoir, and the membrane includes electrode layers separated by insulating layers in which the electrode layers have an organic coating. A nanopore is formed through the membrane, and the organic coating on the electrode layers forms transient bonds to a base of a molecule in the nanopore. When a first voltage is applied to the electrode layers a tunneling current is generated by the base in the nanopore, and the tunneling current travels through the transient bonds formed to the base to be measured as a current signature for distinguishing the base.

DNA sequencing using multiple metal layer structure with organic coatings forming transient bonding to DNA bases

A technique for controlling the motion of one or more charged entities linked to a polymer through a nanochannel is provided. A first reservoir and a second reservoir are connected by the nanochannel. An array of electrodes is positioned along the nanochannel, where fluid fills the first reservoir, the second reservoir, and the nanochannel. A first electrode is in the first reservoir and a second electrode is in the second reservoir. The first and second electrodes are configured to direct the one or more charged entities linked to the polymer into the nanochannel. An array of electrodes is configured to trap the one or more charged entities in the nanochannel responsive to being controlled for trapping. The array of electrodes is configured to move the one or more charged entities along the nanochannel responsive to being controlled for moving.

Charged entities as locomotive to control motion of polymers through a nanochannel

The invention is a pharmaceutical product which may be authenticated, comprising identifying markers disposed in the pharmaceutical product. The pharmaceutical product is selected from the group consisting of a pill, a tablet, a caplet, and a capsule. The identifying markers are gel pellets made from a hydroscopic medium having an indicia imprinted thereon and expand volumetrically when contacted with a liquid.

System and method for authenticating pharmaceuticals using internally located hydroscopic gels with indicia

The invention is the technology of providing a packaging intermediate product that can serve as an interface substrate that is to be positioned between different circuitry types where the dimensions are approaching the sub 100 micrometer range. The invention involves a dielectric wafer structure where the first and second area surfaces of the wafer are separated by a distance that is of the order of the electrical via design length, and an array of spaced vias through the wafer arranged with each via filled with metal surrounded by a chemical metal deposition promoting layer with each via terminating flush with a wafer surface. The wafer structure is achieved by forming an array of blind via openings through the first surface of the dielectric wafer to a depth approaching the via design length, lining the walls for adhesion enhancement, filling the blind via openings completely with a chemically deposited metal, removing material at the first wafer surface thereby planarizing the filled vias, and removing material at the second wafer surface thereby exposing the vias at the design length.

Technology for fabrication of packaging interface substrate wafers with fully metallized vias through the substrate wafer

A method to fabricate a high density, minimal pitch, thermally matched contactor assembly to maintain electrical contact with contact regions on fully processed semiconductors, preferably while still in wafer form, and throughout a range of temperatures. A guide plate and a contactor assembly for such use, comprising a substrate formed of a material having a coefficient of thermal expansion approximately equal to that of the device; and at least one hole in the guide plate for receiving an electrical contact (probe element) for contacting at least one respective region on said surface, said at least one hole being sized and shaped so as to accept said electrical contact, while allowing said electrical contact (probe element) to move with respect to said hole in said guide plate. The material can be one of silicon, borosilicate glass and cordierite.

Method for producing thermally matched probe assembly

Growing community of inventors

New York, NY, United States of America

George Frederick Walker