Other

The Scripps Research Institute

The Salk Institute for Biological Studies

Mapreg

Laser Vision Centers, Inc.

George F Koob

Wylie W Vale, Jr

Mary P Stenzel-Poore

Isabelle Villey

Etienne Baulieu

Olivier George

Barbara Jean Mason

Stephen C Heinrichs

The present invention relates to the use of non-bioconvertible C-substituted pregnenolone derivatives of formula (I), with no significant affinity for hormonal receptors or receptors of the central nervous system, in the treatment of substance use disorders, and in particular of alcohol use disorder.

Non-bioconvertible C-substituted pregnenolone derivatives for use in the treatment of substance use disorders

The present invention provides a device for flushing a cavitation plate water intake outboard motor. The invention includes as coupling for attaching the device to a water source such as a hose, a flow passage for directing water through the device and into the outboard motor, and an attachment portion for attaching the device to the outboard motor.

Flushing device

In accordance with the present invention, there are provided CRF overproducing transgenic mice which exhibit endocrine abnormalities involving the hypothalamic-pituitary-adrenal axis, such as elevated plasma levels of ACTH and glucocorticoids. The transgenic mice of the present invention represent a genetic model of CRF overproduction, providing a valuable tool for investigating the long term effects of CRF excess and dysregulation in the central nervous system.

Corticotropin-releasing factor overproducing transgenic mice

A mobile laser surgical center includes a truck body in which the surgical center is housed and a truck cab which transports the surgical center from one location to another. The surgical center includes a laser, a control for the laser and a patient seat. The truck body includes a floor, side walls, and a top. The laser is secured to the floor such that substantially no realignment of the laser is needed when the center is transported between locations. The truck body is also stabilized so that the truck body floor will be maintained in a level condition during a surgical procedure.

Mobile laser surgical center

Growing community of inventors

Rancho Santa Fe, CA, United States of America

George F Koob