Amgen Inc.

George Erich Wohlhieter

Qingping Zeng

Celia Dominguez

Matthew Paul Bourbeau

Guomin Yao

James Thomas Rider

Andrew Stewart Tasker

Holger Monenschein

John Gordon Allen

Xianghong Wang

Fang-Tsao Hong

Vellarkad N Viswanadhan

Qingyian Liu

Christopher Harold Fotsch

Chester Chenguang Yuan

Nianhe Han

Aiwen Li

Seifu Tadesse

Matthew Lee

Xin Huang

Kurt E Weiler

Dawei Zhang

James Richard Falsey

Andreas Reichelt

Matthew R Lee

The invention relates to methods of using thiazole compounds of Formula I and Formula II and compositions thereof for treating diseases mediated by protein kinase B (PKB) such as cancer and other proliferative disorders where the variables have the definitions provided herein. 

Thiazole compounds and methods of use

The invention relates to heterocyclic compounds of Formula I and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein.  The invention also relates to the therapeutic use of such compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

Heterocyclic modulators of PKB

The invention relates to thiadiazole compounds useful for treating diseases mediated by protein kinase B (PKB). The invention also relates to the therapeutic use of such thiadiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

Thiadiazole compounds and methods of use

The invention relates to thiazole compounds of Formula I and Formula II and compositions thereof useful for treating diseases mediated by protein kinase B (PKB) where the variables have the definitions provided herein. The invention also relates to the therapeutic use of such thiazole compounds and compositions thereof in treating disease states associated with abnormal cell growth, cancer, inflammation, and metabolic disorders.

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Lake Balboa, CA, United States of America

George Erich Wohlhieter